Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life
المؤلفون المشاركون
Joglekar, Mugdha V.
Permezel, Michael
Georgiou, Harry M.
Willcox, Jane C.
Shub, Alexis
Maynard, Cody-Lee
Hardikar, Anandwardhan A.
Lappas, Martha
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-24
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Women with previous gestational diabetes mellitus (GDM) have evidence of postpartum β-cell dysfunction, which increases their risk of developing type 2 diabetes (T2DM) later in life.
Elevated levels of circulating cell-free preproinsulin (INS) DNA correlate with dying β-cells in both mice and humans.
The aim of this study was to determine if cell-free circulating INS DNA levels are higher in women with previous GDM who develop T2DM.
Methods.
We used droplet digital (dd) PCR to measure the levels of cell-free circulating methylated and unmethylated INS DNA in plasma from 97 women with normal glucose tolerance (NGT), 12 weeks following an index GDM pregnancy.
Women were assessed for up to 10 years for the development of T2DM.
Results.
In the follow-up period, 22% of women developed T2DM.
Compared with NGT women, total cell-free INS DNA levels were significantly higher in women who developed T2DM (P=0.02).
There was no difference in cell-free circulating unmethylated and methylated INS DNA levels between NGT women and women who developed T2DM (P=0.09 and P=0.07, respectively).
Conclusions.
In women with a previous index GDM pregnancy, postpartum levels of cell-free circulating INS DNA are significantly higher in those women who later developed T2DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lappas, Martha& Georgiou, Harry M.& Willcox, Jane C.& Permezel, Michael& Shub, Alexis& Maynard, Cody-Lee…[et al.]. 2019. Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1172881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lappas, Martha…[et al.]. Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life. Journal of Diabetes Research No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1172881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lappas, Martha& Georgiou, Harry M.& Willcox, Jane C.& Permezel, Michael& Shub, Alexis& Maynard, Cody-Lee…[et al.]. Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1172881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر