Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life
Joint Authors
Joglekar, Mugdha V.
Permezel, Michael
Georgiou, Harry M.
Willcox, Jane C.
Shub, Alexis
Maynard, Cody-Lee
Hardikar, Anandwardhan A.
Lappas, Martha
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Women with previous gestational diabetes mellitus (GDM) have evidence of postpartum β-cell dysfunction, which increases their risk of developing type 2 diabetes (T2DM) later in life.
Elevated levels of circulating cell-free preproinsulin (INS) DNA correlate with dying β-cells in both mice and humans.
The aim of this study was to determine if cell-free circulating INS DNA levels are higher in women with previous GDM who develop T2DM.
Methods.
We used droplet digital (dd) PCR to measure the levels of cell-free circulating methylated and unmethylated INS DNA in plasma from 97 women with normal glucose tolerance (NGT), 12 weeks following an index GDM pregnancy.
Women were assessed for up to 10 years for the development of T2DM.
Results.
In the follow-up period, 22% of women developed T2DM.
Compared with NGT women, total cell-free INS DNA levels were significantly higher in women who developed T2DM (P=0.02).
There was no difference in cell-free circulating unmethylated and methylated INS DNA levels between NGT women and women who developed T2DM (P=0.09 and P=0.07, respectively).
Conclusions.
In women with a previous index GDM pregnancy, postpartum levels of cell-free circulating INS DNA are significantly higher in those women who later developed T2DM.
American Psychological Association (APA)
Lappas, Martha& Georgiou, Harry M.& Willcox, Jane C.& Permezel, Michael& Shub, Alexis& Maynard, Cody-Lee…[et al.]. 2019. Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1172881
Modern Language Association (MLA)
Lappas, Martha…[et al.]. Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life. Journal of Diabetes Research No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1172881
American Medical Association (AMA)
Lappas, Martha& Georgiou, Harry M.& Willcox, Jane C.& Permezel, Michael& Shub, Alexis& Maynard, Cody-Lee…[et al.]. Postpartum Circulating Cell-Free Insulin DNA Levels Are Higher in Women with Previous Gestational Diabetes Mellitus Who Develop Type 2 Diabetes in Later Life. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1172881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172881