![](/images/graphics-bg.png)
Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study
المؤلفون المشاركون
Liu, Xue
Jiang, Jingjing
Liu, Xiaotian
Luo, Zhicheng
Wang, Yan
Dong, Xiaokang
Wei, Dandan
Huo, Wenqian
Yu, Songcheng
Li, Linlin
Jin, Shuna
Wang, Chongjian
Mao, Zhenxing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
The aim of the study was to investigate the independent and combined effects of the cortisol-to-cortisone ratio (F/E) and 11-deoxycortisol on prediabetes and type 2 diabetes mellitus (T2DM) among different genders.
Methods.
A case-control study was performed including 2676 participants from the Henan Rural Cohort Study.
Liquid chromatography-tandem mass spectrometry was used to assess serum cortisol, cortisone, and 11-deoxycortisol.
Conditional logistic regression was performed to estimate the associations between hormones and outcomes.
Results.
After adjusting for multiple variables, the negative associations of F/E and 11-dexyocortisol with T2DM were observed in females (T3 vs.
T1: OR=0.56, 95% CI: 0.39-0.80 for F/E; T3 vs.
T1: OR=0.44, 95% CI: 0.27-0.73 for 11-dexyocortisol).
However, only 11-dexyocortisol showed a negative association with prediabetes both in males and females.
Compared with the combination of low F/E and 11-dexyocortisol, the combination of middle F/E and high 11-dexyocortisol was significantly associated with prediabetes (OR=0.29, 95% CI: 0.12-0.71) in males.
Furthermore, the combination of high F/E and 11-dexyocortisol was associated with the lowest odds of prediabetes (OR=0.39, 95% CI: 0.21-0.73) and T2DM (OR=0.25, 95% CI: 0.12-0.52) in females.
Conclusions.
Serum F/E level was negatively associated with T2DM only in females whereas serum 11-deoxycortisol level was negatively associated with prediabetes in males and with prediabetes and T2DM in females.
Additionally, their combination has a synergistic effect on T2DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xue& Jiang, Jingjing& Liu, Xiaotian& Luo, Zhicheng& Wang, Yan& Dong, Xiaokang…[et al.]. 2019. Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1172953
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xue…[et al.]. Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study. Journal of Diabetes Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1172953
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xue& Jiang, Jingjing& Liu, Xiaotian& Luo, Zhicheng& Wang, Yan& Dong, Xiaokang…[et al.]. Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1172953
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1172953
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)