![](/images/graphics-bg.png)
Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study
Joint Authors
Liu, Xue
Jiang, Jingjing
Liu, Xiaotian
Luo, Zhicheng
Wang, Yan
Dong, Xiaokang
Wei, Dandan
Huo, Wenqian
Yu, Songcheng
Li, Linlin
Jin, Shuna
Wang, Chongjian
Mao, Zhenxing
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The aim of the study was to investigate the independent and combined effects of the cortisol-to-cortisone ratio (F/E) and 11-deoxycortisol on prediabetes and type 2 diabetes mellitus (T2DM) among different genders.
Methods.
A case-control study was performed including 2676 participants from the Henan Rural Cohort Study.
Liquid chromatography-tandem mass spectrometry was used to assess serum cortisol, cortisone, and 11-deoxycortisol.
Conditional logistic regression was performed to estimate the associations between hormones and outcomes.
Results.
After adjusting for multiple variables, the negative associations of F/E and 11-dexyocortisol with T2DM were observed in females (T3 vs.
T1: OR=0.56, 95% CI: 0.39-0.80 for F/E; T3 vs.
T1: OR=0.44, 95% CI: 0.27-0.73 for 11-dexyocortisol).
However, only 11-dexyocortisol showed a negative association with prediabetes both in males and females.
Compared with the combination of low F/E and 11-dexyocortisol, the combination of middle F/E and high 11-dexyocortisol was significantly associated with prediabetes (OR=0.29, 95% CI: 0.12-0.71) in males.
Furthermore, the combination of high F/E and 11-dexyocortisol was associated with the lowest odds of prediabetes (OR=0.39, 95% CI: 0.21-0.73) and T2DM (OR=0.25, 95% CI: 0.12-0.52) in females.
Conclusions.
Serum F/E level was negatively associated with T2DM only in females whereas serum 11-deoxycortisol level was negatively associated with prediabetes in males and with prediabetes and T2DM in females.
Additionally, their combination has a synergistic effect on T2DM.
American Psychological Association (APA)
Liu, Xue& Jiang, Jingjing& Liu, Xiaotian& Luo, Zhicheng& Wang, Yan& Dong, Xiaokang…[et al.]. 2019. Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1172953
Modern Language Association (MLA)
Liu, Xue…[et al.]. Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study. Journal of Diabetes Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1172953
American Medical Association (AMA)
Liu, Xue& Jiang, Jingjing& Liu, Xiaotian& Luo, Zhicheng& Wang, Yan& Dong, Xiaokang…[et al.]. Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1172953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1172953