The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis
المؤلفون المشاركون
Poulsen, S. S.
Andreone, Luz
Mandrup-Poulsen, Thomas
Backe, Marie Balslev
Sankar, Aditya
Agger, Karl
Helin, Kristian
Madsen, Andreas Nygaard
Bysani, Madhusudhan
Bacos, Karl
Ling, Charlotte
Perone, Marcelo Javier
Holst, Birgitte
Jin, Chunyu
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Aims.
Posttranslational modifications of histones and transcription factors regulate gene expression and are implicated in beta-cell failure and diabetes.
We have recently shown that preserving H3K27 and H3K4 methylation using the lysine demethylase inhibitor GSK-J4 reduces cytokine-induced destruction of beta-cells and improves beta-cell function.
Here, we investigate the therapeutic potential of GSK-J4 to prevent diabetes development and examine the importance of H3K4 methylation for islet function.
Materials and Methods.
We used two mouse models of diabetes to investigate the therapeutic potential of GSK-J4.
To clarify the importance of H3K4 methylation, we characterized a mouse strain with knockout (KO) of the H3K4 demethylase KDM5B.
Results.
GSK-J4 administration failed to prevent the development of experimental diabetes induced by multiple low-dose streptozotocin or adoptive transfer of splenocytes from acutely diabetic NOD to NODscid mice.
KDM5B-KO mice were growth retarded with altered body composition, had low IGF-1 levels, and exhibited reduced insulin secretion.
Interestingly, despite secreting less insulin, KDM5B-KO mice were able to maintain normoglycemia following oral glucose tolerance test, likely via improved insulin sensitivity, as suggested by insulin tolerance testing and phosphorylation of proteins belonging to the insulin signaling pathway.
When challenged with high-fat diet, KDM5B-deficient mice displayed similar weight gain and insulin sensitivity as wild-type mice.
Conclusion.
Our results show a novel role of KDM5B in metabolism, as KDM5B-KO mice display growth retardation and improved insulin sensitivity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Backe, Marie Balslev& Jin, Chunyu& Andreone, Luz& Sankar, Aditya& Agger, Karl& Helin, Kristian…[et al.]. 2019. The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1173037
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Backe, Marie Balslev…[et al.]. The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis. Journal of Diabetes Research No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1173037
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Backe, Marie Balslev& Jin, Chunyu& Andreone, Luz& Sankar, Aditya& Agger, Karl& Helin, Kristian…[et al.]. The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1173037
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173037
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر