Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats
المؤلفون المشاركون
Hassan, Mohammed H.
Saleem, Tahia H.
Abo El-Maali, Nagwa
Mohamed, Nahed A.
Mostafa, Nashwa A. M.
Abdel-Kahaar, Emaad
Tammam, Azza S.
المصدر
International Journal of Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Aims.
Both paracetamol (PA) and phenacetin (PH) are analgesic and antipyretic agents.
Part of phenacetin therapeutic activity is attributed to its metabolism into paracetamol.
Paracetamol causes direct hepatic oxidative stress damage.
The present study aimed to investigate the possible damaging effects of both PA and PH, when used in therapeutic doses, on rat liver and to compare the antioxidant and hepatoprotective effects of N-acetylcysteine (NAC), N-acetyl-methionine (NAM), and N-acetylglucosamine (NAG) against PA- or PH-induced hepatic damage.
Methods.
90 male Wistar albino rats (120-140 gm) were undertaken, categorized randomly into 9 groups of 10 rats each, and administered by gavage for 2 weeks with DMSO 1% (controls), PA, PA+NAC, PA+NAM, PA+NAG, PH, PH+NAC, PH+NAM, and PH+NAG.
Biochemical assays of malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), total thiols, and alpha-fetoprotein (AFP) in liver homogenates and serum assays of ALT, AST, 8-hydroxy guanine (8-OH-Gua), and AFP were done.
Also histopathological examinations of liver tissues in various groups were done.
Results.
PA and PH cause significant increase in hepatic levels of MDA, NO, and AFP and serum ALT, AST, and 8-OH-Gua levels, with significant decrease in hepatic GSH and total thiols.
NAG and NAC significantly improve the PA- and PH-induced hepatic and blood, biochemical, and histopathological disturbances, respectively.
Conclusions.
Both PA and PH induce oxidative stress in rat liver within their therapeutic doses.
NAG and NAC in pharmacological doses can antagonize the oxidative damaging effect of both PA and PH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saleem, Tahia H.& Abo El-Maali, Nagwa& Hassan, Mohammed H.& Mohamed, Nahed A.& Mostafa, Nashwa A. M.& Abdel-Kahaar, Emaad…[et al.]. 2018. Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats. International Journal of Hepatology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1173063
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saleem, Tahia H.…[et al.]. Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats. International Journal of Hepatology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1173063
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saleem, Tahia H.& Abo El-Maali, Nagwa& Hassan, Mohammed H.& Mohamed, Nahed A.& Mostafa, Nashwa A. M.& Abdel-Kahaar, Emaad…[et al.]. Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats. International Journal of Hepatology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1173063
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173063
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر