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Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats
Joint Authors
Hassan, Mohammed H.
Saleem, Tahia H.
Abo El-Maali, Nagwa
Mohamed, Nahed A.
Mostafa, Nashwa A. M.
Abdel-Kahaar, Emaad
Tammam, Azza S.
Source
International Journal of Hepatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aims.
Both paracetamol (PA) and phenacetin (PH) are analgesic and antipyretic agents.
Part of phenacetin therapeutic activity is attributed to its metabolism into paracetamol.
Paracetamol causes direct hepatic oxidative stress damage.
The present study aimed to investigate the possible damaging effects of both PA and PH, when used in therapeutic doses, on rat liver and to compare the antioxidant and hepatoprotective effects of N-acetylcysteine (NAC), N-acetyl-methionine (NAM), and N-acetylglucosamine (NAG) against PA- or PH-induced hepatic damage.
Methods.
90 male Wistar albino rats (120-140 gm) were undertaken, categorized randomly into 9 groups of 10 rats each, and administered by gavage for 2 weeks with DMSO 1% (controls), PA, PA+NAC, PA+NAM, PA+NAG, PH, PH+NAC, PH+NAM, and PH+NAG.
Biochemical assays of malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), total thiols, and alpha-fetoprotein (AFP) in liver homogenates and serum assays of ALT, AST, 8-hydroxy guanine (8-OH-Gua), and AFP were done.
Also histopathological examinations of liver tissues in various groups were done.
Results.
PA and PH cause significant increase in hepatic levels of MDA, NO, and AFP and serum ALT, AST, and 8-OH-Gua levels, with significant decrease in hepatic GSH and total thiols.
NAG and NAC significantly improve the PA- and PH-induced hepatic and blood, biochemical, and histopathological disturbances, respectively.
Conclusions.
Both PA and PH induce oxidative stress in rat liver within their therapeutic doses.
NAG and NAC in pharmacological doses can antagonize the oxidative damaging effect of both PA and PH.
American Psychological Association (APA)
Saleem, Tahia H.& Abo El-Maali, Nagwa& Hassan, Mohammed H.& Mohamed, Nahed A.& Mostafa, Nashwa A. M.& Abdel-Kahaar, Emaad…[et al.]. 2018. Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats. International Journal of Hepatology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1173063
Modern Language Association (MLA)
Saleem, Tahia H.…[et al.]. Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats. International Journal of Hepatology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1173063
American Medical Association (AMA)
Saleem, Tahia H.& Abo El-Maali, Nagwa& Hassan, Mohammed H.& Mohamed, Nahed A.& Mostafa, Nashwa A. M.& Abdel-Kahaar, Emaad…[et al.]. Comparative Protective Effects of N-Acetylcysteine, N-Acetyl Methionine, and N-Acetyl Glucosamine against Paracetamol and Phenacetin Therapeutic Doses–Induced Hepatotoxicity in Rats. International Journal of Hepatology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1173063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173063