Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine
المؤلفون المشاركون
Osafo, Newman
Woode, Eric
Benneh, Charles
Boakye-Gyasi, Eric
Ampadu, Felix Agyei
Ekuadzi, Edmund
المصدر
International Journal of Inflammation
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Maerua angolensis has been used traditionally in the management of pain, arthritis, and rheumatism in Ghana and Nigeria but no scientific evidence is currently available to give credence to its folkloric use.
The aim of this study was therefore to evaluate the anti-inflammatory effects of a stem bark extract of Maerua angolensis DC (MAE) in acute inflammatory models.
The effects of MAE (30-300 mg kg−1) on neutrophil infiltration, exudate volume, and endogenous antioxidant enzymes in lung tissues and lung morphology were evaluated with the carrageenan induced pleurisy model in Sprague Dawley rats.
The effects of MAE (30-300 mg kg−1) on vascular permeability were also evaluated in the acetic acid induced vascular permeability in ICR mice.
MAE significantly reduced neutrophil infiltration, exudate volume, and lung tissue damage in carrageenan induced pleurisy.
MAE increased the activities of antioxidant enzymes glutathione, superoxide dismutase, and catalase in lung tissues.
The extract was also able to reduce myeloperoxidase activity and lipid peroxidation in lung tissues in carrageenan induced rat pleurisy.
Vascular permeability was also attenuated by the extract with marked reduction of Evans blue dye leakage in acetic acid induced permeability assay.
The results indicated that Maerua angolensis is effective in ameliorating inflammation induced by carrageenan and acetic acid.
It also has the potential of increasing the activity of endogenous antioxidant enzymes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ampadu, Felix Agyei& Boakye-Gyasi, Eric& Osafo, Newman& Benneh, Charles& Ekuadzi, Edmund& Woode, Eric. 2018. Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine. International Journal of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1173252
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ampadu, Felix Agyei…[et al.]. Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine. International Journal of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1173252
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ampadu, Felix Agyei& Boakye-Gyasi, Eric& Osafo, Newman& Benneh, Charles& Ekuadzi, Edmund& Woode, Eric. Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine. International Journal of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1173252
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173252
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر