Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine
Joint Authors
Osafo, Newman
Woode, Eric
Benneh, Charles
Boakye-Gyasi, Eric
Ampadu, Felix Agyei
Ekuadzi, Edmund
Source
International Journal of Inflammation
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Maerua angolensis has been used traditionally in the management of pain, arthritis, and rheumatism in Ghana and Nigeria but no scientific evidence is currently available to give credence to its folkloric use.
The aim of this study was therefore to evaluate the anti-inflammatory effects of a stem bark extract of Maerua angolensis DC (MAE) in acute inflammatory models.
The effects of MAE (30-300 mg kg−1) on neutrophil infiltration, exudate volume, and endogenous antioxidant enzymes in lung tissues and lung morphology were evaluated with the carrageenan induced pleurisy model in Sprague Dawley rats.
The effects of MAE (30-300 mg kg−1) on vascular permeability were also evaluated in the acetic acid induced vascular permeability in ICR mice.
MAE significantly reduced neutrophil infiltration, exudate volume, and lung tissue damage in carrageenan induced pleurisy.
MAE increased the activities of antioxidant enzymes glutathione, superoxide dismutase, and catalase in lung tissues.
The extract was also able to reduce myeloperoxidase activity and lipid peroxidation in lung tissues in carrageenan induced rat pleurisy.
Vascular permeability was also attenuated by the extract with marked reduction of Evans blue dye leakage in acetic acid induced permeability assay.
The results indicated that Maerua angolensis is effective in ameliorating inflammation induced by carrageenan and acetic acid.
It also has the potential of increasing the activity of endogenous antioxidant enzymes.
American Psychological Association (APA)
Ampadu, Felix Agyei& Boakye-Gyasi, Eric& Osafo, Newman& Benneh, Charles& Ekuadzi, Edmund& Woode, Eric. 2018. Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine. International Journal of Inflammation،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1173252
Modern Language Association (MLA)
Ampadu, Felix Agyei…[et al.]. Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine. International Journal of Inflammation No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1173252
American Medical Association (AMA)
Ampadu, Felix Agyei& Boakye-Gyasi, Eric& Osafo, Newman& Benneh, Charles& Ekuadzi, Edmund& Woode, Eric. Antipleuritic and Vascular Permeability Inhibition of the Ethyl Acetate-Petroleum Ether Stem Bark Extract of Maerua angolensis DC (Capparaceae) in Murine. International Journal of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1173252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1173252