Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2HO-1 and NF-κB Pathways
المؤلفون المشاركون
Chen, Bi-Cheng
Zhu, Xiandong
Guo, Feixia
Tang, Hengjie
Huang, Chongchu
Xie, Gangyin
Huang, Tingting
Li, Yonglin
Liu, Chengyang
Wang, Hongwei
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Testicular structural and functional impairment is a serious complication in male diabetes mellitus (DM) patients that leads to impaired fertility in adulthood.
In contrast to other endocrine therapies, islet transplantation (IT) can effectively prevent and even reverse diabetic nephropathy and myocardial damage.
However, whether IT can alleviate diabetes-induced testicular injury remains unclear.
In this study, we sought to investigate the effect of IT on diabetes-induced testicular damage.
A diabetic rat model was established by streptozotocin injection.
DM, IT, and insulin treatment (INS) groups were compared after 4 weeks of respective treatment.
We confirmed that IT could effectively attenuate diabetes-induced testicular damage and recover sperm counts more extensively compared with INS in diabetic rats.
In addition, significantly higher levels of superoxide dismutase (SOD) activity and lower contents of malondialdehyde (MDA) were detected in the testes of the IT group versus diabetic rats.
Mechanism studies revealed that IT significantly activates the expression of Nrf-2, HO-1, and NQO-1 and inhibits upregulation of the NF-κB expression in response to DM, while INS only exhibit slight impact on the protein expression.
Therefore, we speculate that IT may prevent the progression of testicular damage by downregulating oxidative stress and inhibiting inflammation via Nrf-2/HO-1 and NF-κB pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Xiandong& Guo, Feixia& Tang, Hengjie& Huang, Chongchu& Xie, Gangyin& Huang, Tingting…[et al.]. 2019. Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2HO-1 and NF-κB Pathways. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1173330
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Xiandong…[et al.]. Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2HO-1 and NF-κB Pathways. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1173330
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Xiandong& Guo, Feixia& Tang, Hengjie& Huang, Chongchu& Xie, Gangyin& Huang, Tingting…[et al.]. Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2HO-1 and NF-κB Pathways. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1173330
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173330
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر