Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2HO-1 and NF-κB Pathways

Joint Authors

Chen, Bi-Cheng
Zhu, Xiandong
Guo, Feixia
Tang, Hengjie
Huang, Chongchu
Xie, Gangyin
Huang, Tingting
Li, Yonglin
Liu, Chengyang
Wang, Hongwei

Source

Journal of Diabetes Research

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-09-05

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases
Medicine

Abstract EN

Testicular structural and functional impairment is a serious complication in male diabetes mellitus (DM) patients that leads to impaired fertility in adulthood.

In contrast to other endocrine therapies, islet transplantation (IT) can effectively prevent and even reverse diabetic nephropathy and myocardial damage.

However, whether IT can alleviate diabetes-induced testicular injury remains unclear.

In this study, we sought to investigate the effect of IT on diabetes-induced testicular damage.

A diabetic rat model was established by streptozotocin injection.

DM, IT, and insulin treatment (INS) groups were compared after 4 weeks of respective treatment.

We confirmed that IT could effectively attenuate diabetes-induced testicular damage and recover sperm counts more extensively compared with INS in diabetic rats.

In addition, significantly higher levels of superoxide dismutase (SOD) activity and lower contents of malondialdehyde (MDA) were detected in the testes of the IT group versus diabetic rats.

Mechanism studies revealed that IT significantly activates the expression of Nrf-2, HO-1, and NQO-1 and inhibits upregulation of the NF-κB expression in response to DM, while INS only exhibit slight impact on the protein expression.

Therefore, we speculate that IT may prevent the progression of testicular damage by downregulating oxidative stress and inhibiting inflammation via Nrf-2/HO-1 and NF-κB pathways.

American Psychological Association (APA)

Zhu, Xiandong& Guo, Feixia& Tang, Hengjie& Huang, Chongchu& Xie, Gangyin& Huang, Tingting…[et al.]. 2019. Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2HO-1 and NF-κB Pathways. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1173330

Modern Language Association (MLA)

Zhu, Xiandong…[et al.]. Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2HO-1 and NF-κB Pathways. Journal of Diabetes Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1173330

American Medical Association (AMA)

Zhu, Xiandong& Guo, Feixia& Tang, Hengjie& Huang, Chongchu& Xie, Gangyin& Huang, Tingting…[et al.]. Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2HO-1 and NF-κB Pathways. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1173330

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1173330