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Coffea canephora Peptides in Combinatorial Treatment with Fluconazole: Antimicrobial Activity against Phytopathogenic Fungus
المؤلفون المشاركون
Bard, Gabriela C. V.
Taveira, Gabriel B.
Souza, Thaynã A. M.
Mello, Érica O.
Souza, Sávio B.
Ramos, Alessandro C.
Carvalho, André O.
Pereira, Lídia S.
Zottich, Umberto
Rodrigues, Rosana
Gomes, Valdirene M.
المصدر
International Journal of Microbiology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The objective of the present study was to evaluate the antimicrobial activity of the Cc-LTP2 and Cc-GRP peptides isolated from Coffea canephora seeds and their possible synergistic activity with the azole drug fluconazole and characterize their mechanisms of action on cells of pathogenic fungi.
Cc-LTP2 and Cc-GRP alone or in combination with 20 µg/mL of fluconazole were evaluated for their antimicrobial activity on the fungus Fusarium solani, and the effects of these peptides on the permeability of membranes and the induction of oxidative stress were determined.
Our results show that these peptides at a concentration of 400 µg/mL combined with 20 µg/mL of fluconazole were able to inhibit the growth of the tested fungi, promote changes in their growth pattern, permeabilize the membrane, and induce reactive oxygen species (ROS).
Some of these results were also observed with the peptides alone or with fluconazole alone, suggesting that the peptides act synergistically, promoting the potentiation of antimicrobial action.
In this study, it was shown that Cc-LTP2 and Cc-GRP in combination with fluconazole were able to inhibit the growth of the fungus F.
solani, to promote permeabilization of its membrane, and to induce the production of ROS, suggesting a combinatorial activity between the peptides and fluconazole.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bard, Gabriela C. V.& Taveira, Gabriel B.& Souza, Thaynã A. M.& Mello, Érica O.& Souza, Sávio B.& Ramos, Alessandro C.…[et al.]. 2018. Coffea canephora Peptides in Combinatorial Treatment with Fluconazole: Antimicrobial Activity against Phytopathogenic Fungus. International Journal of Microbiology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1173402
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bard, Gabriela C. V.…[et al.]. Coffea canephora Peptides in Combinatorial Treatment with Fluconazole: Antimicrobial Activity against Phytopathogenic Fungus. International Journal of Microbiology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1173402
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bard, Gabriela C. V.& Taveira, Gabriel B.& Souza, Thaynã A. M.& Mello, Érica O.& Souza, Sávio B.& Ramos, Alessandro C.…[et al.]. Coffea canephora Peptides in Combinatorial Treatment with Fluconazole: Antimicrobial Activity against Phytopathogenic Fungus. International Journal of Microbiology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1173402
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173402
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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