Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes
المؤلفون المشاركون
Takeda, Yuji
Shimomura, Tomoko
Asao, Hironobu
Wakabayashi, Ichiro
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
A better understanding of pathogenic mechanisms is required in order to treat diseases.
However, the mechanisms of diabetes mellitus and diabetic complications are extremely complex.
Immune reactions are involved in the pathogenesis of diabetes and its complications, while diabetes influences immune reactions.
Furthermore, both diabetes and immune reactions are influenced by genetic and environmental factors.
To address these issues, animal models are useful tools.
So far, various animal models of diabetes have been developed in rats, which have advantages over mice models in terms of the larger volume of tissue samples and the variety of type 2 diabetes models.
In this review, we introduce rat models of diabetes and summarize the immune reactions in diabetic rat models.
Finally, we speculate on the relationship between immune reactions and diabetic episodes.
For example, diabetes-prone Biobreeding rats, type 1 diabetes model rats, exhibit increased autoreactive cellular and inflammatory immune reactions, while Goto-Kakizaki rats, type 2 diabetes model rats, exhibit increased Th2 reactions and attenuation of phagocytic activity.
Investigation of immunological abnormalities in various diabetic rat models is useful for elucidating complicated mechanisms in the pathophysiology of diabetes.
Studying immunological alterations, such as predominance of Th1/17 or Th2 cells, humoral immunity, and innate immune reactions, may improve understanding the structure of amplification circuits for diabetes in future studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takeda, Yuji& Shimomura, Tomoko& Asao, Hironobu& Wakabayashi, Ichiro. 2017. Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174274
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takeda, Yuji…[et al.]. Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1174274
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takeda, Yuji& Shimomura, Tomoko& Asao, Hironobu& Wakabayashi, Ichiro. Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174274
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174274
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر