Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes
Joint Authors
Takeda, Yuji
Shimomura, Tomoko
Asao, Hironobu
Wakabayashi, Ichiro
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A better understanding of pathogenic mechanisms is required in order to treat diseases.
However, the mechanisms of diabetes mellitus and diabetic complications are extremely complex.
Immune reactions are involved in the pathogenesis of diabetes and its complications, while diabetes influences immune reactions.
Furthermore, both diabetes and immune reactions are influenced by genetic and environmental factors.
To address these issues, animal models are useful tools.
So far, various animal models of diabetes have been developed in rats, which have advantages over mice models in terms of the larger volume of tissue samples and the variety of type 2 diabetes models.
In this review, we introduce rat models of diabetes and summarize the immune reactions in diabetic rat models.
Finally, we speculate on the relationship between immune reactions and diabetic episodes.
For example, diabetes-prone Biobreeding rats, type 1 diabetes model rats, exhibit increased autoreactive cellular and inflammatory immune reactions, while Goto-Kakizaki rats, type 2 diabetes model rats, exhibit increased Th2 reactions and attenuation of phagocytic activity.
Investigation of immunological abnormalities in various diabetic rat models is useful for elucidating complicated mechanisms in the pathophysiology of diabetes.
Studying immunological alterations, such as predominance of Th1/17 or Th2 cells, humoral immunity, and innate immune reactions, may improve understanding the structure of amplification circuits for diabetes in future studies.
American Psychological Association (APA)
Takeda, Yuji& Shimomura, Tomoko& Asao, Hironobu& Wakabayashi, Ichiro. 2017. Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174274
Modern Language Association (MLA)
Takeda, Yuji…[et al.]. Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1174274
American Medical Association (AMA)
Takeda, Yuji& Shimomura, Tomoko& Asao, Hironobu& Wakabayashi, Ichiro. Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174274