Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-αNF-κB Signaling Pathway in Diabetic Rats
المؤلفون المشاركون
Zhou, Jingwei
Liu, Wei Jing
Wang, Zhen
Lv, Jie
Wang, Ying
Sun, Weiwei
Wang, Mengdi
Wang, Yaoxian
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and satisfactory therapeutic strategies have not yet been established.
The Shen-Yan-Fang-Shuai Formula (SYFSF) is a traditional Chinese formula composed of Astragali radix, Radixangelicae sinensis, Rheum officinale Baill, and four other herbs.
It has been widely used as an effective treatment for DKD patients in China.
However, little is known about the molecular mechanisms underlying SYFSF’s renoprotection.
In this study, we compared the protective effect of SYFSF to irbesartan on the histology and renal cells in type 2 DKD rat model and high-glucose (HG) cultured mesangial cells, respectively.
We found that SYFSF could significantly decrease urinary albumin, cholesterol, and triglyceride.
And a decrease in serum creatinine was also found in SYFSF-treated group compared with irbesartan-treated rats.
In addition, SYFSF inhibited the interstitial expansion and glomerulosclerosis in diabetic rats.
Notably, SYFSF markedly downregulated the expression of MCP-1, TGF-β1, collagen IV, and fibronectin in diabetic rat models and HG-induced mesangial cell models.
The renoprotection was closely associated with a reduced expression of TNF-α and phosphorylated NF-κBp65.
Our study suggests that SYFSF may ameliorate diabetic kidney injury.
The observed renoprotection is probably attributable to an inhibition of inflammatory response and extracellular matrix (ECM) accumulation mediated by TNF-α/NF-κBp65 signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lv, Jie& Wang, Zhen& Wang, Ying& Sun, Weiwei& Zhou, Jingwei& Wang, Mengdi…[et al.]. 2017. Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-αNF-κB Signaling Pathway in Diabetic Rats. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174281
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lv, Jie…[et al.]. Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-αNF-κB Signaling Pathway in Diabetic Rats. Journal of Diabetes Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1174281
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lv, Jie& Wang, Zhen& Wang, Ying& Sun, Weiwei& Zhou, Jingwei& Wang, Mengdi…[et al.]. Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-αNF-κB Signaling Pathway in Diabetic Rats. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174281
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174281
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر