![](/images/graphics-bg.png)
Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-αNF-κB Signaling Pathway in Diabetic Rats
Joint Authors
Zhou, Jingwei
Liu, Wei Jing
Wang, Zhen
Lv, Jie
Wang, Ying
Sun, Weiwei
Wang, Mengdi
Wang, Yaoxian
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and satisfactory therapeutic strategies have not yet been established.
The Shen-Yan-Fang-Shuai Formula (SYFSF) is a traditional Chinese formula composed of Astragali radix, Radixangelicae sinensis, Rheum officinale Baill, and four other herbs.
It has been widely used as an effective treatment for DKD patients in China.
However, little is known about the molecular mechanisms underlying SYFSF’s renoprotection.
In this study, we compared the protective effect of SYFSF to irbesartan on the histology and renal cells in type 2 DKD rat model and high-glucose (HG) cultured mesangial cells, respectively.
We found that SYFSF could significantly decrease urinary albumin, cholesterol, and triglyceride.
And a decrease in serum creatinine was also found in SYFSF-treated group compared with irbesartan-treated rats.
In addition, SYFSF inhibited the interstitial expansion and glomerulosclerosis in diabetic rats.
Notably, SYFSF markedly downregulated the expression of MCP-1, TGF-β1, collagen IV, and fibronectin in diabetic rat models and HG-induced mesangial cell models.
The renoprotection was closely associated with a reduced expression of TNF-α and phosphorylated NF-κBp65.
Our study suggests that SYFSF may ameliorate diabetic kidney injury.
The observed renoprotection is probably attributable to an inhibition of inflammatory response and extracellular matrix (ECM) accumulation mediated by TNF-α/NF-κBp65 signaling pathway.
American Psychological Association (APA)
Lv, Jie& Wang, Zhen& Wang, Ying& Sun, Weiwei& Zhou, Jingwei& Wang, Mengdi…[et al.]. 2017. Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-αNF-κB Signaling Pathway in Diabetic Rats. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174281
Modern Language Association (MLA)
Lv, Jie…[et al.]. Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-αNF-κB Signaling Pathway in Diabetic Rats. Journal of Diabetes Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1174281
American Medical Association (AMA)
Lv, Jie& Wang, Zhen& Wang, Ying& Sun, Weiwei& Zhou, Jingwei& Wang, Mengdi…[et al.]. Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-αNF-κB Signaling Pathway in Diabetic Rats. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174281