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Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy
المؤلفون المشاركون
Li, Zheng
Yu, Hanjie
Zhu, Hanyu
Liu, Moyan
Liu, Xiawei
Zhong, Yaogang
Shu, Jian
Fu, Xinle
Cai, Guangyan
Chen, Xiangmei
Geng, Wenjia
Yang, Xiaoli
Wu, Minghui
Zhang, Dong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Diabetic nephropathy is a major cause of chronic kidney disease and end-stage kidney disease.
However, so little is known about alterations of the glycopatterns in urine with the development of diabetic nephropathy.
Presently, we interrogated glycopatterns in urine specimens using a lectin microarray.
The results showed that expression levels of Siaα2-6Gal/GalNAc recognized by SNA exhibited significantly increased tendency with the development of diabetic nephropathy; moreover, SNA blotting indicated glycoproteins (90 kDa, 70 kDa, and 40 kDa) in urine may contribute to this alteration.
Furthermore, the glycopatterns of (GlcNAc)2–4 recognized by STL exhibited difference between diabetic and nondiabetic nephropathy.
The results of urinary protein microarray fabricated by another 48 urine specimens also indicated (GlcNAc)2–4 is a potential indictor to differentiate the patients with diabetic nephropathy from nondiabetic nephropathy.
Furtherly, STL blotting showed that the 50 kDa glycoproteins were correlated with this alteration.
In conclusion, our data provide pivotal information to monitor the development of diabetic nephropathy and distinguish between diabetic nephropathy and nondiabetic renal disease based on precise alterations of glycopatterns in urinary proteins, but further studies are needed in this regard.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Hanyu& Liu, Moyan& Yu, Hanjie& Liu, Xiawei& Zhong, Yaogang& Shu, Jian…[et al.]. 2017. Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1174471
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Hanyu…[et al.]. Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy. Journal of Diabetes Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1174471
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Hanyu& Liu, Moyan& Yu, Hanjie& Liu, Xiawei& Zhong, Yaogang& Shu, Jian…[et al.]. Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1174471
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174471
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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