Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy
Joint Authors
Li, Zheng
Yu, Hanjie
Zhu, Hanyu
Liu, Moyan
Liu, Xiawei
Zhong, Yaogang
Shu, Jian
Fu, Xinle
Cai, Guangyan
Chen, Xiangmei
Geng, Wenjia
Yang, Xiaoli
Wu, Minghui
Zhang, Dong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Diabetic nephropathy is a major cause of chronic kidney disease and end-stage kidney disease.
However, so little is known about alterations of the glycopatterns in urine with the development of diabetic nephropathy.
Presently, we interrogated glycopatterns in urine specimens using a lectin microarray.
The results showed that expression levels of Siaα2-6Gal/GalNAc recognized by SNA exhibited significantly increased tendency with the development of diabetic nephropathy; moreover, SNA blotting indicated glycoproteins (90 kDa, 70 kDa, and 40 kDa) in urine may contribute to this alteration.
Furthermore, the glycopatterns of (GlcNAc)2–4 recognized by STL exhibited difference between diabetic and nondiabetic nephropathy.
The results of urinary protein microarray fabricated by another 48 urine specimens also indicated (GlcNAc)2–4 is a potential indictor to differentiate the patients with diabetic nephropathy from nondiabetic nephropathy.
Furtherly, STL blotting showed that the 50 kDa glycoproteins were correlated with this alteration.
In conclusion, our data provide pivotal information to monitor the development of diabetic nephropathy and distinguish between diabetic nephropathy and nondiabetic renal disease based on precise alterations of glycopatterns in urinary proteins, but further studies are needed in this regard.
American Psychological Association (APA)
Zhu, Hanyu& Liu, Moyan& Yu, Hanjie& Liu, Xiawei& Zhong, Yaogang& Shu, Jian…[et al.]. 2017. Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1174471
Modern Language Association (MLA)
Zhu, Hanyu…[et al.]. Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy. Journal of Diabetes Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1174471
American Medical Association (AMA)
Zhu, Hanyu& Liu, Moyan& Yu, Hanjie& Liu, Xiawei& Zhong, Yaogang& Shu, Jian…[et al.]. Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1174471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174471