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Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus
المؤلفون المشاركون
Wang, Ping
Xi, Shoumin
Liu, Huili
Chen, Li
Duan, Yingli
Chen, Qunli
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Glucokinase (GK) plays a critical role in the control of whole-body glucose homeostasis.
We investigated the possible effects of a novel glucokinase activator (GKA), HMS5552, to the GK in rats with type 2 diabetes mellitus (T2DM).
Male Sprague-Dawley (SD) rats were divided into four groups: control group, diabetic group, low-dose (10 mg/kg) HMS5552-treated diabetic group (HMS-L), and high-dose (30 mg/kg) HMS5552-treated diabetic group (HMS-H).
HMS5552 was administered intragastrically to the T2DM rats for one month.
The levels of total cholesterol, triglyceride, fasting plasma insulin (FINS), and glucagon (FG) were determined, and an oral glucose tolerance test was performed.
The expression patterns of proteins and genes associated with insulin resistance and GK activity were assayed.
Compared with diabetic rats, the FINS level was significantly decreased in the HMS5552-treated diabetic rats.
HMS5552 treatment significantly lowered the blood glucose levels and improved GK activity and insulin resistance.
The immunohistochemistry, western blot, and semiquantitative RT-PCR results further demonstrated the effects of HMS5552 on the liver and pancreas.
Our data suggest that the novel GKA, HMS5552, exerts antidiabetic effects on the liver and pancreas by improving GK activity and insulin resistance, which holds promise as a novel drug for the treatment of T2DM patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ping& Liu, Huili& Chen, Li& Duan, Yingli& Chen, Qunli& Xi, Shoumin. 2017. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ping…[et al.]. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1174488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ping& Liu, Huili& Chen, Li& Duan, Yingli& Chen, Qunli& Xi, Shoumin. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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