Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus
Joint Authors
Wang, Ping
Xi, Shoumin
Liu, Huili
Chen, Li
Duan, Yingli
Chen, Qunli
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Glucokinase (GK) plays a critical role in the control of whole-body glucose homeostasis.
We investigated the possible effects of a novel glucokinase activator (GKA), HMS5552, to the GK in rats with type 2 diabetes mellitus (T2DM).
Male Sprague-Dawley (SD) rats were divided into four groups: control group, diabetic group, low-dose (10 mg/kg) HMS5552-treated diabetic group (HMS-L), and high-dose (30 mg/kg) HMS5552-treated diabetic group (HMS-H).
HMS5552 was administered intragastrically to the T2DM rats for one month.
The levels of total cholesterol, triglyceride, fasting plasma insulin (FINS), and glucagon (FG) were determined, and an oral glucose tolerance test was performed.
The expression patterns of proteins and genes associated with insulin resistance and GK activity were assayed.
Compared with diabetic rats, the FINS level was significantly decreased in the HMS5552-treated diabetic rats.
HMS5552 treatment significantly lowered the blood glucose levels and improved GK activity and insulin resistance.
The immunohistochemistry, western blot, and semiquantitative RT-PCR results further demonstrated the effects of HMS5552 on the liver and pancreas.
Our data suggest that the novel GKA, HMS5552, exerts antidiabetic effects on the liver and pancreas by improving GK activity and insulin resistance, which holds promise as a novel drug for the treatment of T2DM patients.
American Psychological Association (APA)
Wang, Ping& Liu, Huili& Chen, Li& Duan, Yingli& Chen, Qunli& Xi, Shoumin. 2017. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174488
Modern Language Association (MLA)
Wang, Ping…[et al.]. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1174488
American Medical Association (AMA)
Wang, Ping& Liu, Huili& Chen, Li& Duan, Yingli& Chen, Qunli& Xi, Shoumin. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174488