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Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus
المؤلفون المشاركون
Hatzitolios, Apostolos I.
Tziomalos, Konstantinos
Didangelos, T.
Karlafti, Eleni
Margaritidis, Charalambos
Kontoninas, Zisis
Stergiou, Ioannis
Tsotoulidis, Stefanos
Mourouglakis, Alexandros
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
To evaluate the effect of quinapril on diabetic cardiovascular autonomic neuropathy (CAN) and peripheral neuropathy (DPN).
Patients and Methods.
Sixty-three consecutive patients with diabetes mellitus [43% males, 27 with type 1 DM, mean age 52 years (range 22–65)], definite DCAN [abnormal results in 2 cardiovascular autonomic reflex tests (CARTs)], and DPN were randomized to quinapril 20 mg/day (group A, n=31) or placebo (group B, n=32) for 2 years.
Patients with hypertension or coronary heart disease were excluded.
To detect DPN and DCAN, the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE), measurement of vibration perception threshold with biothesiometer (BIO), and CARTs [R-R variation during deep breathing [assessed by expiration/inspiration ratio (E/I), mean circular resultant (MCR), and standard deviation (SD)], Valsalva maneuver (Vals), 30 : 15 ratio, and orthostatic hypotension (OH)] were used.
Results.
In group A, E/I, MCR, and SD increased (p for all comparisons < 0.05).
Other indices (Vals, 30 : 15, OH, MNSIQ, MNSIE, and BIO) did not change.
In group B, all CART indices deteriorated, except Vals, which did not change.
MNSIQ, MNSIE, and BIO did not change.
Conclusions.
Treatment with quinapril improves DCAN (mainly parasympathetic dysfunction).
Improved autonomic balance may improve the long-term outcome of diabetic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Didangelos, T.& Tziomalos, Konstantinos& Margaritidis, Charalambos& Kontoninas, Zisis& Stergiou, Ioannis& Tsotoulidis, Stefanos…[et al.]. 2017. Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174623
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Didangelos, T.…[et al.]. Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus. Journal of Diabetes Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1174623
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Didangelos, T.& Tziomalos, Konstantinos& Margaritidis, Charalambos& Kontoninas, Zisis& Stergiou, Ioannis& Tsotoulidis, Stefanos…[et al.]. Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174623
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174623
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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