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Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus
Joint Authors
Hatzitolios, Apostolos I.
Tziomalos, Konstantinos
Didangelos, T.
Karlafti, Eleni
Margaritidis, Charalambos
Kontoninas, Zisis
Stergiou, Ioannis
Tsotoulidis, Stefanos
Mourouglakis, Alexandros
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To evaluate the effect of quinapril on diabetic cardiovascular autonomic neuropathy (CAN) and peripheral neuropathy (DPN).
Patients and Methods.
Sixty-three consecutive patients with diabetes mellitus [43% males, 27 with type 1 DM, mean age 52 years (range 22–65)], definite DCAN [abnormal results in 2 cardiovascular autonomic reflex tests (CARTs)], and DPN were randomized to quinapril 20 mg/day (group A, n=31) or placebo (group B, n=32) for 2 years.
Patients with hypertension or coronary heart disease were excluded.
To detect DPN and DCAN, the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE), measurement of vibration perception threshold with biothesiometer (BIO), and CARTs [R-R variation during deep breathing [assessed by expiration/inspiration ratio (E/I), mean circular resultant (MCR), and standard deviation (SD)], Valsalva maneuver (Vals), 30 : 15 ratio, and orthostatic hypotension (OH)] were used.
Results.
In group A, E/I, MCR, and SD increased (p for all comparisons < 0.05).
Other indices (Vals, 30 : 15, OH, MNSIQ, MNSIE, and BIO) did not change.
In group B, all CART indices deteriorated, except Vals, which did not change.
MNSIQ, MNSIE, and BIO did not change.
Conclusions.
Treatment with quinapril improves DCAN (mainly parasympathetic dysfunction).
Improved autonomic balance may improve the long-term outcome of diabetic patients.
American Psychological Association (APA)
Didangelos, T.& Tziomalos, Konstantinos& Margaritidis, Charalambos& Kontoninas, Zisis& Stergiou, Ioannis& Tsotoulidis, Stefanos…[et al.]. 2017. Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174623
Modern Language Association (MLA)
Didangelos, T.…[et al.]. Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus. Journal of Diabetes Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1174623
American Medical Association (AMA)
Didangelos, T.& Tziomalos, Konstantinos& Margaritidis, Charalambos& Kontoninas, Zisis& Stergiou, Ioannis& Tsotoulidis, Stefanos…[et al.]. Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174623