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Urinary Exosomal MicroRNA Profiling in Incipient Type 2 Diabetic Kidney Disease
المؤلفون المشاركون
Hu, Fang
Jia, Yijie
Xue, Yaoming
Xie, Yijun
Cuihua, Xie
Xue, Meng
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Albuminuria is an early sign but not a strong predictor of diabetic kidney disease (DKD).
Owing to their high stability, urinary exosomal miRNAs can be useful predictors of the progression of early-stage DKD to renal failure; fluid biopsies are ideal for detecting abnormalities in these miRNAs.
The aim of this study was to identify novel differentially expressed miRNAs as urine biomarkers for type 2 DKD by comparing between patients of type 2 diabetes (T2D) with and without macroalbuminuria.
Methods.
Ten patients with T2D, including five who had no renal disease and five with macroalbuminuria (DKD G1-2A3), were selected for this study.
Exosome- (UExo-) derived miRNA profiles were used to identify candidate biomarkers, a subset of which was verified using quantitative reverse transcription PCR.
Results.
A total of 496 UExo-derived miRNA species were found to be differentially expressed (>2-fold) in patients with DKD, compared to those with T2D.
A validation analysis revealed that three miRNAs (miR-362-3p, miR-877-3p, and miR-150-5p) were upregulated and one (miR-15a-5p) was downregulated.
These miRNAs might regulate DKD through p53, mTOR, and AMPK pathways.
Conclusions.
In conclusion, UExo-derived miRNAs were altered in type 2 DKD.
MiR-362-3p, miR-877-3p, miR-150-5p, and miR-15a-5p might be novel biomarkers for incipient DKD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Yijun& Jia, Yijie& Cuihua, Xie& Hu, Fang& Xue, Meng& Xue, Yaoming. 2017. Urinary Exosomal MicroRNA Profiling in Incipient Type 2 Diabetic Kidney Disease. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1174644
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Yijun…[et al.]. Urinary Exosomal MicroRNA Profiling in Incipient Type 2 Diabetic Kidney Disease. Journal of Diabetes Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1174644
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Yijun& Jia, Yijie& Cuihua, Xie& Hu, Fang& Xue, Meng& Xue, Yaoming. Urinary Exosomal MicroRNA Profiling in Incipient Type 2 Diabetic Kidney Disease. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1174644
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174644
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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