Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention andor Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes
المؤلفون المشاركون
Ji, Linong
Yang, Jin-kui
Guo, Xiaohui
Chen, Wei
Zhou, Xianghai
Luo, Yingying
Paul, Sanjoy K.
Chang, Cuiqing
Wang, Hongyuan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Patients with prediabetes are at high risk for diabetes and cardiovascular disease (CVD).
No study has explored whether intervention could revert prediabetes to normal glycemic status as the primary outcome.
Beijing Prediabetes Reversion Program (BPRP) would evaluate whether intensive lifestyle modification and/or pioglitazone could revert prediabetic state to normoglycemia and improve the risk factors of CVD as well.
Methods.
BPRP is a randomized, multicenter, 2 × 2 factorial design study.
Participants diagnosed as prediabetes were randomized into four groups (conventional/intensive lifestyle intervention and 30 mg pioglitazone/placebo) with a three-year follow-up.
The primary endpoint was conversion into normal glucose tolerance.
The trial would recruit 2000 participants (500 in each arm).
Results.
Between March 2007 and March 2011, 1945 participants were randomized.
At baseline, the individuals were 53±10 years old, with median BMI 26.0 (23.9, 28.2) kg/m2 and HbA1c 5.8 (5.6, 6.1)%.
85% of the participants had IGT and 15% had IFG.
Parameters relevant to glucose, lipids, blood pressure, lifestyle, and other metabolic markers were similar between conventional and intensive lifestyle intervention group at baseline.
Conclusion.
BPRP was the first study to determine if lifestyle modification and/or pioglitazone could revert prediabetic state to normoglycemia in Chinese population.
Major baseline parameters were balanced between two lifestyle intervention groups.
This trial is registered with www.chictr.org.cn: ChiCTR-PRC-06000005.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, Yingying& Paul, Sanjoy K.& Zhou, Xianghai& Chang, Cuiqing& Chen, Wei& Guo, Xiaohui…[et al.]. 2017. Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention andor Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174728
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, Yingying…[et al.]. Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention andor Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1174728
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, Yingying& Paul, Sanjoy K.& Zhou, Xianghai& Chang, Cuiqing& Chen, Wei& Guo, Xiaohui…[et al.]. Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention andor Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174728
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174728
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر