Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention andor Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes
Joint Authors
Ji, Linong
Yang, Jin-kui
Guo, Xiaohui
Chen, Wei
Zhou, Xianghai
Luo, Yingying
Paul, Sanjoy K.
Chang, Cuiqing
Wang, Hongyuan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Patients with prediabetes are at high risk for diabetes and cardiovascular disease (CVD).
No study has explored whether intervention could revert prediabetes to normal glycemic status as the primary outcome.
Beijing Prediabetes Reversion Program (BPRP) would evaluate whether intensive lifestyle modification and/or pioglitazone could revert prediabetic state to normoglycemia and improve the risk factors of CVD as well.
Methods.
BPRP is a randomized, multicenter, 2 × 2 factorial design study.
Participants diagnosed as prediabetes were randomized into four groups (conventional/intensive lifestyle intervention and 30 mg pioglitazone/placebo) with a three-year follow-up.
The primary endpoint was conversion into normal glucose tolerance.
The trial would recruit 2000 participants (500 in each arm).
Results.
Between March 2007 and March 2011, 1945 participants were randomized.
At baseline, the individuals were 53±10 years old, with median BMI 26.0 (23.9, 28.2) kg/m2 and HbA1c 5.8 (5.6, 6.1)%.
85% of the participants had IGT and 15% had IFG.
Parameters relevant to glucose, lipids, blood pressure, lifestyle, and other metabolic markers were similar between conventional and intensive lifestyle intervention group at baseline.
Conclusion.
BPRP was the first study to determine if lifestyle modification and/or pioglitazone could revert prediabetic state to normoglycemia in Chinese population.
Major baseline parameters were balanced between two lifestyle intervention groups.
This trial is registered with www.chictr.org.cn: ChiCTR-PRC-06000005.
American Psychological Association (APA)
Luo, Yingying& Paul, Sanjoy K.& Zhou, Xianghai& Chang, Cuiqing& Chen, Wei& Guo, Xiaohui…[et al.]. 2017. Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention andor Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174728
Modern Language Association (MLA)
Luo, Yingying…[et al.]. Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention andor Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1174728
American Medical Association (AMA)
Luo, Yingying& Paul, Sanjoy K.& Zhou, Xianghai& Chang, Cuiqing& Chen, Wei& Guo, Xiaohui…[et al.]. Rationale, Design, and Baseline Characteristics of Beijing Prediabetes Reversion Program: A Randomized Controlled Clinical Trial to Evaluate the Efficacy of Lifestyle Intervention andor Pioglitazone in Reversion to Normal Glucose Tolerance in Prediabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174728