Sympathetic Denervation Accelerates Wound Contraction but Inhibits Reepithelialization and Pericyte Proliferation in Diabetic Mice
المؤلفون المشاركون
Zheng, Zhifang
Wan, Yu
Liu, Yishu
Yang, Yu
Tang, Jianbing
Huang, Wenhua
Cheng, Biao
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Previous studies focused on the effects of sympathetic denervation with 6-hydroxydopamine (6-OHDA) on nondiabetic wounds, but the effects of 6-OHDA on diabetic wounds have not been previously reported.
In this study, treated mice received intraperitoneal 6-OHDA, and control mice received intraperitoneal injections of normal saline.
Full-thickness wounds were established on the backs of mice.
The wounds were sectioned (four mice per group) for analysis at 2, 5, 7, 10, 14, 17, and 21 days after injury.
The wound areas in the control group were larger than those in the treatment group.
Histological scores for epidermal and dermal regeneration were reduced in the 6-OHDA-treated group on day 21.
The mast cells (MCs) in each field decreased after sympathectomy on days 17 and 21.
The expression levels of norepinephrine, epidermal growth factor (EGF), interleukin-1 beta, NG2 proteoglycan, and desmin in the treatment group were less than those in the control group.
In conclusion, 6-OHDA delays reepithelialization during wound healing in diabetic mice by decreasing EGF, but increases wound contraction by reducing IL-1β levels and the number of MCs.
Besides, 6-OHDA led to reduced pericyte proliferation in diabetic wounds, which might explain the vascular dysfunction after sympathetic nerve loss in diabetic wounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Zhifang& Wan, Yu& Liu, Yishu& Yang, Yu& Tang, Jianbing& Huang, Wenhua…[et al.]. 2017. Sympathetic Denervation Accelerates Wound Contraction but Inhibits Reepithelialization and Pericyte Proliferation in Diabetic Mice. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174735
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Zhifang…[et al.]. Sympathetic Denervation Accelerates Wound Contraction but Inhibits Reepithelialization and Pericyte Proliferation in Diabetic Mice. Journal of Diabetes Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1174735
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Zhifang& Wan, Yu& Liu, Yishu& Yang, Yu& Tang, Jianbing& Huang, Wenhua…[et al.]. Sympathetic Denervation Accelerates Wound Contraction but Inhibits Reepithelialization and Pericyte Proliferation in Diabetic Mice. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174735
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174735
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر