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Sympathetic Denervation Accelerates Wound Contraction but Inhibits Reepithelialization and Pericyte Proliferation in Diabetic Mice
Joint Authors
Zheng, Zhifang
Wan, Yu
Liu, Yishu
Yang, Yu
Tang, Jianbing
Huang, Wenhua
Cheng, Biao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Previous studies focused on the effects of sympathetic denervation with 6-hydroxydopamine (6-OHDA) on nondiabetic wounds, but the effects of 6-OHDA on diabetic wounds have not been previously reported.
In this study, treated mice received intraperitoneal 6-OHDA, and control mice received intraperitoneal injections of normal saline.
Full-thickness wounds were established on the backs of mice.
The wounds were sectioned (four mice per group) for analysis at 2, 5, 7, 10, 14, 17, and 21 days after injury.
The wound areas in the control group were larger than those in the treatment group.
Histological scores for epidermal and dermal regeneration were reduced in the 6-OHDA-treated group on day 21.
The mast cells (MCs) in each field decreased after sympathectomy on days 17 and 21.
The expression levels of norepinephrine, epidermal growth factor (EGF), interleukin-1 beta, NG2 proteoglycan, and desmin in the treatment group were less than those in the control group.
In conclusion, 6-OHDA delays reepithelialization during wound healing in diabetic mice by decreasing EGF, but increases wound contraction by reducing IL-1β levels and the number of MCs.
Besides, 6-OHDA led to reduced pericyte proliferation in diabetic wounds, which might explain the vascular dysfunction after sympathetic nerve loss in diabetic wounds.
American Psychological Association (APA)
Zheng, Zhifang& Wan, Yu& Liu, Yishu& Yang, Yu& Tang, Jianbing& Huang, Wenhua…[et al.]. 2017. Sympathetic Denervation Accelerates Wound Contraction but Inhibits Reepithelialization and Pericyte Proliferation in Diabetic Mice. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174735
Modern Language Association (MLA)
Zheng, Zhifang…[et al.]. Sympathetic Denervation Accelerates Wound Contraction but Inhibits Reepithelialization and Pericyte Proliferation in Diabetic Mice. Journal of Diabetes Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1174735
American Medical Association (AMA)
Zheng, Zhifang& Wan, Yu& Liu, Yishu& Yang, Yu& Tang, Jianbing& Huang, Wenhua…[et al.]. Sympathetic Denervation Accelerates Wound Contraction but Inhibits Reepithelialization and Pericyte Proliferation in Diabetic Mice. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174735