Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract
المؤلفون المشاركون
Shi, Ji
Jia, Tian-zhu
Ren, Xiaohang
Wang, Jia
Wei, Xiaofeng
Liu, Bonan
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Salt processing, which involves steaming with salt water, directs herbs into the kidney channel.
After being salt processed, kidney invigorating effects occur.
However, the underlying mechanism of this method remains elusive.
The compounds monotropein, rubiadin, and rubiadin 1-methyl ether are the major effective components of Morinda officinalis How.
To clarify the pharmacokinetics and tissue distribution of these three compounds, we employed liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to determine the contents of the three components in rat plasma and tissues.
Separation was achieved on an Acquity UPLC HSS T3 column (100 mm × 2.1 mm, 1.8 μm, Waters).
Formic acid aqueous solution (0.1%; A) and acetonitrile (containing 0.1% formic acid; B) were used as the mobile phase system with a programmed elution of 0∼5 min with 70% A and then 5∼7 min with 60% A.
All analytes were measured with optimized multiple reaction monitoring (MRM) in negative ion mode.
Geniposide and 1,8-dihydroxyanthraquinone were used as the internal standards (IS).
The linear ranges were 1.2∼190, 1.3∼510, and 0.047∼37.5 μg/mL, respectively.
Compared with the Morinda officinalis without wood (MO) group, the Cmax and AUC0-t parameters of rubiadin and rubiadin 1-methyl ether elevated remarkably for the salt-processed Morinda officinalis (SMO) groups, which indicates that steaming by salt could increase the bioavailability of rubiadin and rubiadin 1-methyl ether.
The Tmax for monotropein is shorter (0.5 h) in SMO groups than that in MO group, which means that monotropein was quickly absorbed in the SMO extract.
Moreover, the contents of three compounds in the small intestine were the highest.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Ji& Ren, Xiaohang& Wang, Jia& Wei, Xiaofeng& Liu, Bonan& Jia, Tian-zhu. 2020. Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1174761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Ji…[et al.]. Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1174761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Ji& Ren, Xiaohang& Wang, Jia& Wei, Xiaofeng& Liu, Bonan& Jia, Tian-zhu. Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1174761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر