![](/images/graphics-bg.png)
Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract
Joint Authors
Shi, Ji
Jia, Tian-zhu
Ren, Xiaohang
Wang, Jia
Wei, Xiaofeng
Liu, Bonan
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Salt processing, which involves steaming with salt water, directs herbs into the kidney channel.
After being salt processed, kidney invigorating effects occur.
However, the underlying mechanism of this method remains elusive.
The compounds monotropein, rubiadin, and rubiadin 1-methyl ether are the major effective components of Morinda officinalis How.
To clarify the pharmacokinetics and tissue distribution of these three compounds, we employed liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to determine the contents of the three components in rat plasma and tissues.
Separation was achieved on an Acquity UPLC HSS T3 column (100 mm × 2.1 mm, 1.8 μm, Waters).
Formic acid aqueous solution (0.1%; A) and acetonitrile (containing 0.1% formic acid; B) were used as the mobile phase system with a programmed elution of 0∼5 min with 70% A and then 5∼7 min with 60% A.
All analytes were measured with optimized multiple reaction monitoring (MRM) in negative ion mode.
Geniposide and 1,8-dihydroxyanthraquinone were used as the internal standards (IS).
The linear ranges were 1.2∼190, 1.3∼510, and 0.047∼37.5 μg/mL, respectively.
Compared with the Morinda officinalis without wood (MO) group, the Cmax and AUC0-t parameters of rubiadin and rubiadin 1-methyl ether elevated remarkably for the salt-processed Morinda officinalis (SMO) groups, which indicates that steaming by salt could increase the bioavailability of rubiadin and rubiadin 1-methyl ether.
The Tmax for monotropein is shorter (0.5 h) in SMO groups than that in MO group, which means that monotropein was quickly absorbed in the SMO extract.
Moreover, the contents of three compounds in the small intestine were the highest.
American Psychological Association (APA)
Shi, Ji& Ren, Xiaohang& Wang, Jia& Wei, Xiaofeng& Liu, Bonan& Jia, Tian-zhu. 2020. Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1174761
Modern Language Association (MLA)
Shi, Ji…[et al.]. Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1174761
American Medical Association (AMA)
Shi, Ji& Ren, Xiaohang& Wang, Jia& Wei, Xiaofeng& Liu, Bonan& Jia, Tian-zhu. Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1174761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174761