Coordination of Nanoconjugation with an AntigenAntibody for Efficient Detection of Gynecological Tumors
المؤلفون المشاركون
Chen, Yeng
Gopinath, Subash C. B.
Liu, Xinmei
Yang, Xinyuan
Shao, Juan
Hong, Yufeng
Wey, Mang Chek
Wang, Yaru
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cervical, ovarian, and endometrial cancers are common in the female reproductive system.
Cervical cancer starts from the cervix, while ovarian cancer develops when abnormal cells grow in the ovary.
Endometrial or uterine cancer starts from the lining of the womb in the endometrium.
Approximately 12,000 women are affected every year by cervical cancer in the United States.
Squamous cell carcinoma antigen (SCC-Ag) is a well-established biomarker in serum for diagnosing gynecological cancers, and its levels were observed to be elevated in cervical, ovarian, and endometrial cancer patients.
Moreover, SCC-Ag was used to identify the tumor size and progression stages.
Various biosensing systems have been proposed to identify SCC-Ag; herein, enhanced interdigitated electrode sensing is presented with the use of gold nanoparticles (GNPs) to conjugate an antigen/antibody.
It was proved that the limit of detection is 62.5 fM in the case of antibody-GNP, which is 2-fold higher than that by SCC-Ag-GNP.
Furthermore, the antibody-GNP-modified surface displays greater current increases with concomitant dose-dependent SCC-Ag levels.
High analytical performance was shown by the discrimination against α-fetoprotein and CYFRA 21-1 at 1 pM.
An enhanced sensing system is established for gynecological tumors, representing an advance from the earlier detection methods.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xinmei& Yang, Xinyuan& Shao, Juan& Hong, Yufeng& Gopinath, Subash C. B.& Chen, Yeng…[et al.]. 2020. Coordination of Nanoconjugation with an AntigenAntibody for Efficient Detection of Gynecological Tumors. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174786
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xinmei…[et al.]. Coordination of Nanoconjugation with an AntigenAntibody for Efficient Detection of Gynecological Tumors. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1174786
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xinmei& Yang, Xinyuan& Shao, Juan& Hong, Yufeng& Gopinath, Subash C. B.& Chen, Yeng…[et al.]. Coordination of Nanoconjugation with an AntigenAntibody for Efficient Detection of Gynecological Tumors. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174786
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174786
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر