Coordination of Nanoconjugation with an AntigenAntibody for Efficient Detection of Gynecological Tumors
Joint Authors
Chen, Yeng
Gopinath, Subash C. B.
Liu, Xinmei
Yang, Xinyuan
Shao, Juan
Hong, Yufeng
Wey, Mang Chek
Wang, Yaru
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cervical, ovarian, and endometrial cancers are common in the female reproductive system.
Cervical cancer starts from the cervix, while ovarian cancer develops when abnormal cells grow in the ovary.
Endometrial or uterine cancer starts from the lining of the womb in the endometrium.
Approximately 12,000 women are affected every year by cervical cancer in the United States.
Squamous cell carcinoma antigen (SCC-Ag) is a well-established biomarker in serum for diagnosing gynecological cancers, and its levels were observed to be elevated in cervical, ovarian, and endometrial cancer patients.
Moreover, SCC-Ag was used to identify the tumor size and progression stages.
Various biosensing systems have been proposed to identify SCC-Ag; herein, enhanced interdigitated electrode sensing is presented with the use of gold nanoparticles (GNPs) to conjugate an antigen/antibody.
It was proved that the limit of detection is 62.5 fM in the case of antibody-GNP, which is 2-fold higher than that by SCC-Ag-GNP.
Furthermore, the antibody-GNP-modified surface displays greater current increases with concomitant dose-dependent SCC-Ag levels.
High analytical performance was shown by the discrimination against α-fetoprotein and CYFRA 21-1 at 1 pM.
An enhanced sensing system is established for gynecological tumors, representing an advance from the earlier detection methods.
American Psychological Association (APA)
Liu, Xinmei& Yang, Xinyuan& Shao, Juan& Hong, Yufeng& Gopinath, Subash C. B.& Chen, Yeng…[et al.]. 2020. Coordination of Nanoconjugation with an AntigenAntibody for Efficient Detection of Gynecological Tumors. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174786
Modern Language Association (MLA)
Liu, Xinmei…[et al.]. Coordination of Nanoconjugation with an AntigenAntibody for Efficient Detection of Gynecological Tumors. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1174786
American Medical Association (AMA)
Liu, Xinmei& Yang, Xinyuan& Shao, Juan& Hong, Yufeng& Gopinath, Subash C. B.& Chen, Yeng…[et al.]. Coordination of Nanoconjugation with an AntigenAntibody for Efficient Detection of Gynecological Tumors. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174786