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RP-HPLC and UV Spectrophotometric Analysis of Paracetamol, Ibuprofen, and Caffeine in Solid Pharmaceutical Dosage Forms by Derivative, Fourier, and Wavelet Transforms: A Comparison Study
المؤلفون المشاركون
Truong Thi Thu, Huong
Dong Thi Ha, Ly
Nguyen Mai, Huong
Hoang, Vu Dang
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Different signal-transforming algorithms were applied for UV spectrophotometric analysis of paracetamol, ibuprofen, and caffeine in ternary mixtures.
Phosphate buffer pH 7.2 was used as the spectrophotometric solvent.
Severe overlapping spectra could be resolved into individual bands in the range of wavelengths 200–300 nm by using Savitzky–Golay smoothing and differentiation, trigonometric Fourier series, and mother wavelet functions (i.e., sym6, haar, coif3, and mexh).
To optimize spectral recoveries, the concentration of various types of divisors (single, double, and successive) was tested.
The developed spectrophotometric methods showed linearity over the ranges 20–40 mg/L for paracetamol, 12–32 mg/L for ibuprofen, and 1–3.5 mg/L for caffeine (R2 > 0.990).
They could be successfully applied to the assay and dissolution test of paracetamol, ibuprofen, and caffeine in their combined tablets and capsules, with accuracy (99.1–101.5% recovery) and precision (RSD < 2%).
For comparison, an isocratic RP-HPLC analysis was also developed and validated on an Agilent ZORBAX Eclipse XDB–C18 (150 × 4.6 mm, 5 µm) at an ambient temperature.
A mixture of methanol : phosphate buffer 0.01 M pH 3 (30 : 70 v/v) was used as the mobile phase delivered at 2 mL/min, and the effluent was monitored at 225 nm.
It was shown that spectrophotometric data were statistically comparable to HPLC p>0.05, suggesting possible interchange between UV spectrophotometric and HPLC methods for routine analysis of paracetamol, ibuprofen, and caffeine in their solid pharmaceutical dosage forms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hoang, Vu Dang& Truong Thi Thu, Huong& Dong Thi Ha, Ly& Nguyen Mai, Huong. 2020. RP-HPLC and UV Spectrophotometric Analysis of Paracetamol, Ibuprofen, and Caffeine in Solid Pharmaceutical Dosage Forms by Derivative, Fourier, and Wavelet Transforms: A Comparison Study. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1174864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hoang, Vu Dang…[et al.]. RP-HPLC and UV Spectrophotometric Analysis of Paracetamol, Ibuprofen, and Caffeine in Solid Pharmaceutical Dosage Forms by Derivative, Fourier, and Wavelet Transforms: A Comparison Study. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1174864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hoang, Vu Dang& Truong Thi Thu, Huong& Dong Thi Ha, Ly& Nguyen Mai, Huong. RP-HPLC and UV Spectrophotometric Analysis of Paracetamol, Ibuprofen, and Caffeine in Solid Pharmaceutical Dosage Forms by Derivative, Fourier, and Wavelet Transforms: A Comparison Study. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1174864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1174864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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