Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MSMS

المؤلفون المشاركون

Jin, Bo
Zhang, Tingting
Ma, Chen
Xu, Dan
Zhang, Gui-Qiu

المصدر

Journal of Analytical Methods in Chemistry

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-04-01

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الكيمياء

الملخص EN

Naringenin (NAR), 4′,5,7-trihydroxydihydroflavone, has a wide range of pharmacological activities but shows poor water solubility and low bioavailability.

The pharmacokinetics and bioavailability of naringenin-nicotinamide cocrystal (NAR-NCT), which offers improved solubility, were evaluated in this study.

Rats were orally administered NAR, a physical mixture of naringenin and nicotinamide (NAR + NCT), and NAR-NCT.

The relative bioavailability of NAR-NCT was 175.09% of NAR, Cmax was 8.43 and 2.06 times of NAR and NAR + NCT, respectively, Tmax was advanced from 0.49 h to 0.09 h, CL was decreased from 91.1 L/h/kg to 49.1 L/h/kg, and t1/2 was increased from 5.37 h to 8.24 h, highlighting its rapid absorption and slow elimination.

This study showed that NAR-NCT could improve the bioavailability of NAR.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xu, Dan& Zhang, Gui-Qiu& Zhang, Tingting& Jin, Bo& Ma, Chen. 2020. Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MSMS. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1174872

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xu, Dan…[et al.]. Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MSMS. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1174872

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xu, Dan& Zhang, Gui-Qiu& Zhang, Tingting& Jin, Bo& Ma, Chen. Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MSMS. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1174872

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1174872