Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MSMS
Joint Authors
Jin, Bo
Zhang, Tingting
Ma, Chen
Xu, Dan
Zhang, Gui-Qiu
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Naringenin (NAR), 4′,5,7-trihydroxydihydroflavone, has a wide range of pharmacological activities but shows poor water solubility and low bioavailability.
The pharmacokinetics and bioavailability of naringenin-nicotinamide cocrystal (NAR-NCT), which offers improved solubility, were evaluated in this study.
Rats were orally administered NAR, a physical mixture of naringenin and nicotinamide (NAR + NCT), and NAR-NCT.
The relative bioavailability of NAR-NCT was 175.09% of NAR, Cmax was 8.43 and 2.06 times of NAR and NAR + NCT, respectively, Tmax was advanced from 0.49 h to 0.09 h, CL was decreased from 91.1 L/h/kg to 49.1 L/h/kg, and t1/2 was increased from 5.37 h to 8.24 h, highlighting its rapid absorption and slow elimination.
This study showed that NAR-NCT could improve the bioavailability of NAR.
American Psychological Association (APA)
Xu, Dan& Zhang, Gui-Qiu& Zhang, Tingting& Jin, Bo& Ma, Chen. 2020. Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MSMS. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1174872
Modern Language Association (MLA)
Xu, Dan…[et al.]. Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MSMS. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1174872
American Medical Association (AMA)
Xu, Dan& Zhang, Gui-Qiu& Zhang, Tingting& Jin, Bo& Ma, Chen. Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MSMS. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1174872
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174872