ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives
المؤلفون المشاركون
Brunetta, Enrico
Shiffer, Dana
Folci, Marco
Ramponi, Giacomo
Zumbo, Aurora
Agosti, Michele
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The purpose of this paper is to collect and summarize all evidences relating to an association between ANCA-associated vasculitides (AAVs) and hematologic malignancies, in the form of either a paraneoplastic vasculitis or leukemias and lymphomas developing on a preexisting vasculitis.
Additionally, the role of cyclophosphamide in vasculitis treatment has been assessed and compared to rituximab.
Paraneoplastic AAV seems to be an uncommon presentation of hemopathies.
Hematologic malignancy risk in AAV is more likely to be increased by cyclophosphamide, although not yet definitely proven.
Furthermore, the pathogenesis of ANCA-associated vasculitis has been reviewed with particular emphasis on the role of proteinase 3 (PR3) in fuelling granulomatosis with polyangiitis (GPA) inflammation.
PR3 is a bactericidal protein expressed by neutrophilic granules and on their plasma membrane.
Derangements in its expression and function have been linked to leukemias and GPA alike.
PR3-derived PR1 peptide is being studied as an immunotherapy target in leukemia and multiple myeloma.
This study is aimed at bringing together various evidences from the field of immunological and hematological research, at exposing contradictions, and at revealing novel insights on the association between ANCA-associated vasculitis and hematologic malignancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Folci, Marco& Ramponi, Giacomo& Shiffer, Dana& Zumbo, Aurora& Agosti, Michele& Brunetta, Enrico. 2019. ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1175719
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Folci, Marco…[et al.]. ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1175719
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Folci, Marco& Ramponi, Giacomo& Shiffer, Dana& Zumbo, Aurora& Agosti, Michele& Brunetta, Enrico. ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1175719
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1175719
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر