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ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives
Joint Authors
Brunetta, Enrico
Shiffer, Dana
Folci, Marco
Ramponi, Giacomo
Zumbo, Aurora
Agosti, Michele
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The purpose of this paper is to collect and summarize all evidences relating to an association between ANCA-associated vasculitides (AAVs) and hematologic malignancies, in the form of either a paraneoplastic vasculitis or leukemias and lymphomas developing on a preexisting vasculitis.
Additionally, the role of cyclophosphamide in vasculitis treatment has been assessed and compared to rituximab.
Paraneoplastic AAV seems to be an uncommon presentation of hemopathies.
Hematologic malignancy risk in AAV is more likely to be increased by cyclophosphamide, although not yet definitely proven.
Furthermore, the pathogenesis of ANCA-associated vasculitis has been reviewed with particular emphasis on the role of proteinase 3 (PR3) in fuelling granulomatosis with polyangiitis (GPA) inflammation.
PR3 is a bactericidal protein expressed by neutrophilic granules and on their plasma membrane.
Derangements in its expression and function have been linked to leukemias and GPA alike.
PR3-derived PR1 peptide is being studied as an immunotherapy target in leukemia and multiple myeloma.
This study is aimed at bringing together various evidences from the field of immunological and hematological research, at exposing contradictions, and at revealing novel insights on the association between ANCA-associated vasculitis and hematologic malignancies.
American Psychological Association (APA)
Folci, Marco& Ramponi, Giacomo& Shiffer, Dana& Zumbo, Aurora& Agosti, Michele& Brunetta, Enrico. 2019. ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1175719
Modern Language Association (MLA)
Folci, Marco…[et al.]. ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1175719
American Medical Association (AMA)
Folci, Marco& Ramponi, Giacomo& Shiffer, Dana& Zumbo, Aurora& Agosti, Michele& Brunetta, Enrico. ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1175719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175719