Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome
المؤلفون المشاركون
Marinho, Claudio R. F.
Ortolan, Luana S.
Sercundes, Michelle K.
Debone, Daniela
Murillo, Oscar
Epiphanio, Sabrina
Moura, Gabriel Candido
de Castro Quirino, Thatyane
de Sousa Costa, Douglas
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-04
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
The severity of Plasmodium falciparum malaria is associated with parasite cytoadherence, but there is limited knowledge about the effect of parasite cytoadherence in malaria-associated acute respiratory distress syndrome (ARDS).
Our objective was to evaluate the cytoadherence of infected red blood cells (iRBCs) in a murine model of ARDS and to appraise a potential function of endothelial protein C receptor (EPCR) in ARDS pathogenesis.
DBA/2 mice infected with P.
berghei ANKA were classified as ARDS- or hyperparasitemia- (HP-) developing mice according to respiratory parameters and parasitemia.
Lungs, blood, and bronchoalveolar lavage were collected for gene expression or protein analyses.
Primary cultures of microvascular lung endothelial cells from DBA/2 mice were analyzed for iRBC interactions.
Lungs from ARDS-developing mice showed evidence of iRBC accumulation along with an increase in EPCR and TNF concentrations.
Furthermore, TNF increased iRBC adherence in vitro.
Dexamethasone-treated infected mice showed low levels of TNF and EPCR mRNA expression and, finally, decreased vascular permeability, thus protecting mice from ARDS.
In conclusion, we identified that increased iRBC cytoadherence in the lungs underlies malaria-associated ARDS in DBA/2-infected mice and that inflammation increased cytoadherence capacity, suggesting a participation of EPCR and a conceivable target for drug development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ortolan, Luana S.& Sercundes, Michelle K.& Moura, Gabriel Candido& de Castro Quirino, Thatyane& Debone, Daniela& de Sousa Costa, Douglas…[et al.]. 2019. Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1176010
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ortolan, Luana S.…[et al.]. Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome. Journal of Immunology Research No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1176010
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ortolan, Luana S.& Sercundes, Michelle K.& Moura, Gabriel Candido& de Castro Quirino, Thatyane& Debone, Daniela& de Sousa Costa, Douglas…[et al.]. Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1176010
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176010
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر