Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome
Joint Authors
Marinho, Claudio R. F.
Ortolan, Luana S.
Sercundes, Michelle K.
Debone, Daniela
Murillo, Oscar
Epiphanio, Sabrina
Moura, Gabriel Candido
de Castro Quirino, Thatyane
de Sousa Costa, Douglas
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-04
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The severity of Plasmodium falciparum malaria is associated with parasite cytoadherence, but there is limited knowledge about the effect of parasite cytoadherence in malaria-associated acute respiratory distress syndrome (ARDS).
Our objective was to evaluate the cytoadherence of infected red blood cells (iRBCs) in a murine model of ARDS and to appraise a potential function of endothelial protein C receptor (EPCR) in ARDS pathogenesis.
DBA/2 mice infected with P.
berghei ANKA were classified as ARDS- or hyperparasitemia- (HP-) developing mice according to respiratory parameters and parasitemia.
Lungs, blood, and bronchoalveolar lavage were collected for gene expression or protein analyses.
Primary cultures of microvascular lung endothelial cells from DBA/2 mice were analyzed for iRBC interactions.
Lungs from ARDS-developing mice showed evidence of iRBC accumulation along with an increase in EPCR and TNF concentrations.
Furthermore, TNF increased iRBC adherence in vitro.
Dexamethasone-treated infected mice showed low levels of TNF and EPCR mRNA expression and, finally, decreased vascular permeability, thus protecting mice from ARDS.
In conclusion, we identified that increased iRBC cytoadherence in the lungs underlies malaria-associated ARDS in DBA/2-infected mice and that inflammation increased cytoadherence capacity, suggesting a participation of EPCR and a conceivable target for drug development.
American Psychological Association (APA)
Ortolan, Luana S.& Sercundes, Michelle K.& Moura, Gabriel Candido& de Castro Quirino, Thatyane& Debone, Daniela& de Sousa Costa, Douglas…[et al.]. 2019. Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1176010
Modern Language Association (MLA)
Ortolan, Luana S.…[et al.]. Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome. Journal of Immunology Research No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1176010
American Medical Association (AMA)
Ortolan, Luana S.& Sercundes, Michelle K.& Moura, Gabriel Candido& de Castro Quirino, Thatyane& Debone, Daniela& de Sousa Costa, Douglas…[et al.]. Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1176010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176010