Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species
المؤلفون المشاركون
Lockard, Ryan D.
Wilson, Mary E.
Rodríguez, Nilda E.
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-10
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Worldwide, an estimated 12 million people are infected with Leishmania spp.
and an additional 350 million are at risk of infection.
Leishmania are intracellular parasites that cause disease by suppressing macrophage microbicidal responses.
Infection can remain asymptomatic or lead to a spectrum of diseases including cutaneous, mucocutaneous, and visceral leishmaniasis.
Ultimately, the combination of both pathogen and host factors determines the outcome of infection.
Leishmaniasis, as well as numerous other infectious diseases, exhibits sex-related differences that cannot be explained solely in terms of environmental exposure or healthcare access.
Furthermore, transcriptomic evidence is revealing that biological sex is a variable impacting physiology, immune response, drug metabolism, and consequently, the progression of disease.
Herein, we review the distribution, morbidity, and mortality among male and female leishmaniasis patients.
Additionally, we discuss experimental findings and new avenues of research concerning sex-specific responses in cutaneous and visceral leishmaniasis.
The limitations of current therapies and the emergence of drug-resistant parasites underscore the need for new treatments that could harness the host immune response.
As such, understanding the mechanisms driving the differential immune response and disease outcome of males versus females is a necessary step in the development of safer and more effective treatments against leishmaniasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lockard, Ryan D.& Wilson, Mary E.& Rodríguez, Nilda E.. 2019. Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1176172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lockard, Ryan D.…[et al.]. Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species. Journal of Immunology Research No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1176172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lockard, Ryan D.& Wilson, Mary E.& Rodríguez, Nilda E.. Sex-Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1176172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر