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A Convenient and Sensitive LC-MSMS Method for Simultaneous Determination of Carbadox- and Olaquindox-Related Residues in Swine Muscle and Liver Tissues
المؤلفون المشاركون
Huang, Lingli
Zhang, Heying
Qu, Wei
Tao, Yanfei
Chen, Dongmei
Xie, Shuyu
Liu, Zhenli
Pan, Yuanhu
Yuan, Zonghui
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This paper presents a convenient and sensitive LC-MS/MS method for the simultaneous determination of carbadox and olaquindox residues, including desoxyolaquindox (DOLQ), desoxycarbadox (DCBX), quinoxaline-2-carboxylic acid (QCA), 3-methyl-quinoxaline-2-carboxylic acid (MQCA), and the glycine conjugates of QCA and MQCA (namely, QCA-glycine and MQCA-glycine, resp.) in swine muscle and liver tissues.
Tissue samples were extracted with 2% metaphosphoric acid in 20% methanol and cleaned up by solid-phase extraction (SPE) on a mixed-mode anion-exchange column (Oasis MAX).
Analysis was performed on a C18 column by detection with mass spectrometry in the multiple reaction monitoring (MRM) mode.
The limits of detection (LODs) of the six analytes were determined to be 0.01 μg·kg−1 to 0.25 μg·kg−1, and the limits of quantification (LOQs) were 0.02 μg·kg−1 to 0.5 μg·kg−1.
The total recoveries of the six analytes in all tissues were higher than 79.1% with the RSD% less than 9.2%.
The developed method can determine the real residue level of QCA and MQCA, whether they are present in free form or as glycine conjugates in tissues, together with the carcinogenic desoxy metabolites DCBX and DOLQ with high recovery.
Therefore, this method was suitable for routine analysis of residue control programmes and the residue depletion study of CBX and OLQ on swine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Heying& Qu, Wei& Tao, Yanfei& Chen, Dongmei& Xie, Shuyu& Huang, Lingli…[et al.]. 2018. A Convenient and Sensitive LC-MSMS Method for Simultaneous Determination of Carbadox- and Olaquindox-Related Residues in Swine Muscle and Liver Tissues. Journal of Analytical Methods in Chemistry،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1176293
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Heying…[et al.]. A Convenient and Sensitive LC-MSMS Method for Simultaneous Determination of Carbadox- and Olaquindox-Related Residues in Swine Muscle and Liver Tissues. Journal of Analytical Methods in Chemistry No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1176293
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Heying& Qu, Wei& Tao, Yanfei& Chen, Dongmei& Xie, Shuyu& Huang, Lingli…[et al.]. A Convenient and Sensitive LC-MSMS Method for Simultaneous Determination of Carbadox- and Olaquindox-Related Residues in Swine Muscle and Liver Tissues. Journal of Analytical Methods in Chemistry. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1176293
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176293
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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