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The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers
المؤلفون المشاركون
Carvalho, Edgar M.
Carvalho, Natália B.
Amorim, Camila F.
Neto, José Abraão
Santos, Silvane B.
Carvalho, Lucas P.
Grassi, Maria Fernanda Rios
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The cytotoxic activities of CD8+ T cells have been considered the main defense mechanism against the human T lymphotropic virus type 1 (HTLV-1).
As with CD8+ T cells, NK cells can perform cytotoxic degranulation with production of cytotoxic mediators, such as perforins and granzymes.
NK cells are also responsible for antibody-dependent cellular cytotoxicity (ADCC) against infected cells, but few studies have evaluated the role of NK cells in HTLV-1 infection.
The aim of this study was to characterize the subsets and measure the frequency of NK cells in HTLV-1 carriers (HC) and in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and correlate these findings with the proviral load and development of HAM/TSP.
The diagnosis of HTLV-1 infection was performed with a detection antibody against viral antigens by ELISA and confirmed by Western blot.
Phenotypic characterization of NK cells was performed by flow cytometry.
The frequencies of CD56+, CD56+CD3-, CD56+CD16+, and CD56dim cells were decreased in HAM/TSP patients.
The frequency of CD56+CD3- cells was inversely correlated with proviral load in HC but not in HAM/TSP patients.
HAM/TSP patients showed decreased frequency of CD56+ and CD56dim cells expressing CD16, the main receptor for ADCC.
These data indicate that NK cells may play a key role in the control of HTLV-1 infection by preventing the progression of HC to HAM/TSP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amorim, Camila F.& Carvalho, Natália B.& Neto, José Abraão& Santos, Silvane B.& Grassi, Maria Fernanda Rios& Carvalho, Lucas P.…[et al.]. 2019. The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176546
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amorim, Camila F.…[et al.]. The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1176546
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amorim, Camila F.& Carvalho, Natália B.& Neto, José Abraão& Santos, Silvane B.& Grassi, Maria Fernanda Rios& Carvalho, Lucas P.…[et al.]. The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176546
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176546
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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