The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers
Joint Authors
Carvalho, Edgar M.
Carvalho, Natália B.
Amorim, Camila F.
Neto, José Abraão
Santos, Silvane B.
Carvalho, Lucas P.
Grassi, Maria Fernanda Rios
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The cytotoxic activities of CD8+ T cells have been considered the main defense mechanism against the human T lymphotropic virus type 1 (HTLV-1).
As with CD8+ T cells, NK cells can perform cytotoxic degranulation with production of cytotoxic mediators, such as perforins and granzymes.
NK cells are also responsible for antibody-dependent cellular cytotoxicity (ADCC) against infected cells, but few studies have evaluated the role of NK cells in HTLV-1 infection.
The aim of this study was to characterize the subsets and measure the frequency of NK cells in HTLV-1 carriers (HC) and in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and correlate these findings with the proviral load and development of HAM/TSP.
The diagnosis of HTLV-1 infection was performed with a detection antibody against viral antigens by ELISA and confirmed by Western blot.
Phenotypic characterization of NK cells was performed by flow cytometry.
The frequencies of CD56+, CD56+CD3-, CD56+CD16+, and CD56dim cells were decreased in HAM/TSP patients.
The frequency of CD56+CD3- cells was inversely correlated with proviral load in HC but not in HAM/TSP patients.
HAM/TSP patients showed decreased frequency of CD56+ and CD56dim cells expressing CD16, the main receptor for ADCC.
These data indicate that NK cells may play a key role in the control of HTLV-1 infection by preventing the progression of HC to HAM/TSP.
American Psychological Association (APA)
Amorim, Camila F.& Carvalho, Natália B.& Neto, José Abraão& Santos, Silvane B.& Grassi, Maria Fernanda Rios& Carvalho, Lucas P.…[et al.]. 2019. The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176546
Modern Language Association (MLA)
Amorim, Camila F.…[et al.]. The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers. Journal of Immunology Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1176546
American Medical Association (AMA)
Amorim, Camila F.& Carvalho, Natália B.& Neto, José Abraão& Santos, Silvane B.& Grassi, Maria Fernanda Rios& Carvalho, Lucas P.…[et al.]. The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1176546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176546