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Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice
المؤلفون المشاركون
Jiang, Huaji
Chen, Yuhui
Zhang, Zhongmin
Bai, Xiaochun
Jin, Dadi
Cao, He
Sun, Dawei
Lin, Changxin
Wang, Liang
Huang, Minjun
Zhang, Baiyu
المصدر
Journal of Healthcare Engineering
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Bone fracture is a global healthcare issue for high rates of delayed healing and nonunions.
Although n-3 polyunsaturated fatty acid (PUFA) is considered as a beneficial factor for bone metabolism, only few studies till date focused on the effects of n-3 PUFAs on fracture healing.
In this study, we investigated the effect of endogenous n-3 PUFAs on fracture healing by measuring femur fracture repair in both fat-1 transgenic mice and WT mice.
Proximal femoral fracture model was established in fat-1 transgenic mice and WT mice, respectively, and then the fracture was analyzed by using X-ray, micro-computed tomography (micro-CT), and histological assessment at 7, 14, 21, 28, and 35 days after fixation.
The results showed that compared with WT mice, fat-1 mice exhibited acceleration in fracture healing through radiographic and histological analysis (18–21 days versus 21–28 days postfracture).
Meanwhile, X-ray and micro-CT analysis that showed better remodeling callus formation were in the fat-1 group compared to WT group.
Furthermore, histological analysis revealed that endogenous n-3 PUFAs promoted local endochondral ossification and accelerated the remodeling of calcified calluses after fracture.
In conclusion, the present study indicated that endogenously produced n-3 PUFAs promote fracture healing process and accelerate bone remodeling in mice, and supplementation of n-3 PUFAs was positively associated with fracture healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yuhui& Cao, He& Sun, Dawei& Lin, Changxin& Wang, Liang& Huang, Minjun…[et al.]. 2017. Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice. Journal of Healthcare Engineering،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1180900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yuhui…[et al.]. Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice. Journal of Healthcare Engineering No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1180900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yuhui& Cao, He& Sun, Dawei& Lin, Changxin& Wang, Liang& Huang, Minjun…[et al.]. Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice. Journal of Healthcare Engineering. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1180900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1180900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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