Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice
Joint Authors
Jiang, Huaji
Chen, Yuhui
Zhang, Zhongmin
Bai, Xiaochun
Jin, Dadi
Cao, He
Sun, Dawei
Lin, Changxin
Wang, Liang
Huang, Minjun
Zhang, Baiyu
Source
Journal of Healthcare Engineering
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Bone fracture is a global healthcare issue for high rates of delayed healing and nonunions.
Although n-3 polyunsaturated fatty acid (PUFA) is considered as a beneficial factor for bone metabolism, only few studies till date focused on the effects of n-3 PUFAs on fracture healing.
In this study, we investigated the effect of endogenous n-3 PUFAs on fracture healing by measuring femur fracture repair in both fat-1 transgenic mice and WT mice.
Proximal femoral fracture model was established in fat-1 transgenic mice and WT mice, respectively, and then the fracture was analyzed by using X-ray, micro-computed tomography (micro-CT), and histological assessment at 7, 14, 21, 28, and 35 days after fixation.
The results showed that compared with WT mice, fat-1 mice exhibited acceleration in fracture healing through radiographic and histological analysis (18–21 days versus 21–28 days postfracture).
Meanwhile, X-ray and micro-CT analysis that showed better remodeling callus formation were in the fat-1 group compared to WT group.
Furthermore, histological analysis revealed that endogenous n-3 PUFAs promoted local endochondral ossification and accelerated the remodeling of calcified calluses after fracture.
In conclusion, the present study indicated that endogenously produced n-3 PUFAs promote fracture healing process and accelerate bone remodeling in mice, and supplementation of n-3 PUFAs was positively associated with fracture healing.
American Psychological Association (APA)
Chen, Yuhui& Cao, He& Sun, Dawei& Lin, Changxin& Wang, Liang& Huang, Minjun…[et al.]. 2017. Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice. Journal of Healthcare Engineering،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1180900
Modern Language Association (MLA)
Chen, Yuhui…[et al.]. Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice. Journal of Healthcare Engineering No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1180900
American Medical Association (AMA)
Chen, Yuhui& Cao, He& Sun, Dawei& Lin, Changxin& Wang, Liang& Huang, Minjun…[et al.]. Endogenous Production of n-3 Polyunsaturated Fatty Acids Promotes Fracture Healing in Mice. Journal of Healthcare Engineering. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1180900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1180900