Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation
المؤلفون المشاركون
Huang, Xiao-Jun
Zhao, Xiaosu
Zhao, Xiangyu
Huo, Mingrui
Fan, Qiaozhen
Pei, Xuying
Wang, Yu
Zhang, Xiaohui
Xu, Lanping
Liu, Kaiyan
Chang, Yingjun
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Prolonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) has a great impact on transplant outcome.
In this study, we performed a retrospective analysis to investigate the association of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) with PT in 394 patients who underwent unmanipulated haploidentical blood and marrow transplantation (HBMT).
For HLA antibody positive samples with a median fluorescent intensity (MFI) > 500, DSAs were further examined.
A total of 390 patients (99.0%) achieved sustained myeloid engraftment.
Of the 394 cases tested, 45 (11.4%) were DSA positive.
The cumulative incidence of PT in this cohort of patients was 9.9 ± 1.5%.
The incidence of PT was higher in patients with a MFI ≥ 1000 compared with those with a MFI < 1000 (16.8 ± 6.4% versus 7.4 ± 1.4%, P=0.05).
Multivariate analysis showed that the presence of DSAs (MFI ≥ 1000) was correlated to PT (hazard ratio (HR) 3.262; 95% confidence interval (CI), 1.339–7.946; P=0.009) and transplant-related mortality (HR 2.320; 95% CI, 1.169–4.426; P=0.044).
Our results, for the first time, suggest an association of DSAs with PT after unmanipulated HBMT.
It would help screen out the suitable donor and guide intervention.
This indicated that DSAs should be incorporated in the algorithm for unmanipulated HBMT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Xiaosu& Zhao, Xiangyu& Huo, Mingrui& Fan, Qiaozhen& Pei, Xuying& Wang, Yu…[et al.]. 2017. Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181540
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Xiaosu…[et al.]. Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1181540
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Xiaosu& Zhao, Xiangyu& Huo, Mingrui& Fan, Qiaozhen& Pei, Xuying& Wang, Yu…[et al.]. Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181540
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181540
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر