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Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation
Joint Authors
Huang, Xiao-Jun
Zhao, Xiaosu
Zhao, Xiangyu
Huo, Mingrui
Fan, Qiaozhen
Pei, Xuying
Wang, Yu
Zhang, Xiaohui
Xu, Lanping
Liu, Kaiyan
Chang, Yingjun
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Prolonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) has a great impact on transplant outcome.
In this study, we performed a retrospective analysis to investigate the association of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) with PT in 394 patients who underwent unmanipulated haploidentical blood and marrow transplantation (HBMT).
For HLA antibody positive samples with a median fluorescent intensity (MFI) > 500, DSAs were further examined.
A total of 390 patients (99.0%) achieved sustained myeloid engraftment.
Of the 394 cases tested, 45 (11.4%) were DSA positive.
The cumulative incidence of PT in this cohort of patients was 9.9 ± 1.5%.
The incidence of PT was higher in patients with a MFI ≥ 1000 compared with those with a MFI < 1000 (16.8 ± 6.4% versus 7.4 ± 1.4%, P=0.05).
Multivariate analysis showed that the presence of DSAs (MFI ≥ 1000) was correlated to PT (hazard ratio (HR) 3.262; 95% confidence interval (CI), 1.339–7.946; P=0.009) and transplant-related mortality (HR 2.320; 95% CI, 1.169–4.426; P=0.044).
Our results, for the first time, suggest an association of DSAs with PT after unmanipulated HBMT.
It would help screen out the suitable donor and guide intervention.
This indicated that DSAs should be incorporated in the algorithm for unmanipulated HBMT.
American Psychological Association (APA)
Zhao, Xiaosu& Zhao, Xiangyu& Huo, Mingrui& Fan, Qiaozhen& Pei, Xuying& Wang, Yu…[et al.]. 2017. Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181540
Modern Language Association (MLA)
Zhao, Xiaosu…[et al.]. Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1181540
American Medical Association (AMA)
Zhao, Xiaosu& Zhao, Xiangyu& Huo, Mingrui& Fan, Qiaozhen& Pei, Xuying& Wang, Yu…[et al.]. Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181540