![](/images/graphics-bg.png)
Role of CD8 Regulatory T Cells versus Tc1 and Tc17 Cells in the Development of Human Graft-versus-Host Disease
المؤلفون المشاركون
Gutiérrez-Hoya, Adriana
López-Santiago, Rubén
Vela-Ojeda, Jorge
Montiel-Cervantes, Laura
Rodríguez-Cortés, Octavio
Rosales-García, Víctor
Paredes-Cervantes, Vladimir
Flores-Mejía, Raúl
Sandoval-Borrego, Daniela
Moreno-Lafont, Martha
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
CD8+ T cells that secrete proinflammatory cytokines play a central role in exacerbation of inflammation; however, a new subpopulation of CD8 regulatory T cells has recently been characterized.
This study analyzes the prominent role of these different subpopulations in the development of graft-versus-host disease (GVHD).
Samples from 8 healthy donors mobilized with Filgrastim® (G-CSF) and 18 patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) were evaluated by flow cytometry.
Mobilization induced an increase in Tc1 ( p < 0.01 ), Th1 ( p < 0.001 ), Tc17 ( p < 0.05 ), and CD8+IL-10+ cells ( p < 0.05 ), showing that G-CSF induces both pro- and anti-inflammatory profiles.
Donor-patient correlation revealed a trend ( p = 0.06 ) toward the development of GVHD in patients who receive a high percentage of Tc1 cells.
Patients with acute GVHD (aGVHD), either active or controlled, and patients without GVHD were evaluated; patients with active aGVHD had a higher percentage of Tc1 ( p < 0.01 ) and Tc17 ( p < 0.05 ) cells, as opposed to patients without GVHD in whom a higher percentage of CD8 Treg cells ( p < 0.01 ) was found.
These findings indicate that the increase in Tc1 and Tc17 cells is associated with GVHD development, while regulatory CD8 T cells might have a protective role in this disease.
These tests can be used to monitor and control GVHD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gutiérrez-Hoya, Adriana& López-Santiago, Rubén& Vela-Ojeda, Jorge& Montiel-Cervantes, Laura& Rodríguez-Cortés, Octavio& Rosales-García, Víctor…[et al.]. 2017. Role of CD8 Regulatory T Cells versus Tc1 and Tc17 Cells in the Development of Human Graft-versus-Host Disease. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181555
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gutiérrez-Hoya, Adriana…[et al.]. Role of CD8 Regulatory T Cells versus Tc1 and Tc17 Cells in the Development of Human Graft-versus-Host Disease. Journal of Immunology Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1181555
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gutiérrez-Hoya, Adriana& López-Santiago, Rubén& Vela-Ojeda, Jorge& Montiel-Cervantes, Laura& Rodríguez-Cortés, Octavio& Rosales-García, Víctor…[et al.]. Role of CD8 Regulatory T Cells versus Tc1 and Tc17 Cells in the Development of Human Graft-versus-Host Disease. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181555
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181555
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)