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Role of CD8 Regulatory T Cells versus Tc1 and Tc17 Cells in the Development of Human Graft-versus-Host Disease
Joint Authors
Gutiérrez-Hoya, Adriana
López-Santiago, Rubén
Vela-Ojeda, Jorge
Montiel-Cervantes, Laura
Rodríguez-Cortés, Octavio
Rosales-García, Víctor
Paredes-Cervantes, Vladimir
Flores-Mejía, Raúl
Sandoval-Borrego, Daniela
Moreno-Lafont, Martha
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
CD8+ T cells that secrete proinflammatory cytokines play a central role in exacerbation of inflammation; however, a new subpopulation of CD8 regulatory T cells has recently been characterized.
This study analyzes the prominent role of these different subpopulations in the development of graft-versus-host disease (GVHD).
Samples from 8 healthy donors mobilized with Filgrastim® (G-CSF) and 18 patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) were evaluated by flow cytometry.
Mobilization induced an increase in Tc1 ( p < 0.01 ), Th1 ( p < 0.001 ), Tc17 ( p < 0.05 ), and CD8+IL-10+ cells ( p < 0.05 ), showing that G-CSF induces both pro- and anti-inflammatory profiles.
Donor-patient correlation revealed a trend ( p = 0.06 ) toward the development of GVHD in patients who receive a high percentage of Tc1 cells.
Patients with acute GVHD (aGVHD), either active or controlled, and patients without GVHD were evaluated; patients with active aGVHD had a higher percentage of Tc1 ( p < 0.01 ) and Tc17 ( p < 0.05 ) cells, as opposed to patients without GVHD in whom a higher percentage of CD8 Treg cells ( p < 0.01 ) was found.
These findings indicate that the increase in Tc1 and Tc17 cells is associated with GVHD development, while regulatory CD8 T cells might have a protective role in this disease.
These tests can be used to monitor and control GVHD.
American Psychological Association (APA)
Gutiérrez-Hoya, Adriana& López-Santiago, Rubén& Vela-Ojeda, Jorge& Montiel-Cervantes, Laura& Rodríguez-Cortés, Octavio& Rosales-García, Víctor…[et al.]. 2017. Role of CD8 Regulatory T Cells versus Tc1 and Tc17 Cells in the Development of Human Graft-versus-Host Disease. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181555
Modern Language Association (MLA)
Gutiérrez-Hoya, Adriana…[et al.]. Role of CD8 Regulatory T Cells versus Tc1 and Tc17 Cells in the Development of Human Graft-versus-Host Disease. Journal of Immunology Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1181555
American Medical Association (AMA)
Gutiérrez-Hoya, Adriana& López-Santiago, Rubén& Vela-Ojeda, Jorge& Montiel-Cervantes, Laura& Rodríguez-Cortés, Octavio& Rosales-García, Víctor…[et al.]. Role of CD8 Regulatory T Cells versus Tc1 and Tc17 Cells in the Development of Human Graft-versus-Host Disease. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1181555
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181555