The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages
المؤلفون المشاركون
Ribeiro, Maria Nilce Sousa
Fernandes, Elizabeth S.
Teixeira, Simone A.
Monteiro-Neto, Valério
Arruda, Mariana Oliveira
Mendes, Saulo José Figueiredo
de Mesquita, Ludmilla Santos Silva
Galvão, Stanley de Sousa Lima
Muscará, Marcelo Nicolás
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Mentha piperita L.
(peppermint) possesses antimicrobial properties, but little is known of its ability to modulate macrophages.
Macrophages are essential in bacterial infection control due to their antimicrobial functions and ability to link the innate and adaptive immune responses.
We evaluated the effects of the peppermint leaf hydroalcoholic extract (LHAE) on cultured murine peritoneal macrophages stimulated or not with lipopolysaccharide (LPS) in vitro.
Vehicle-treated cells were used as controls.
The constituents of the extract were also identified.
Epicatechin was the major compound detected in the LHAE.
LPS-induced macrophage death was reversed by incubation with LHAE (1–30 μg/ml).
Higher concentrations of the extract (≥100 μg/ml) decreased macrophage viability (49–57%) in the absence of LPS.
LHAE (1–300 μg/ml) attenuated H2O2 (34.6–53.4%) but not nitric oxide production by these cells.
At similar concentrations, the extract increased the activity of superoxide dismutase (15.3–63.5-fold) and glutathione peroxidase (34.4–73.6-fold) in LPS-treated macrophages.
Only LPS-unstimulated macrophages presented enhanced phagocytosis (3.6–6.6-fold increase) when incubated with LHAE (3–30 μg/ml).
Overall, the LHAE obtained from peppermint modulates macrophage-mediated inflammatory responses, by stimulating the antioxidant pathway in these cells.
These effects may be beneficial when the excessive activation of macrophages contributes to tissue damage during infectious disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arruda, Mariana Oliveira& Mendes, Saulo José Figueiredo& Teixeira, Simone A.& de Mesquita, Ludmilla Santos Silva& Ribeiro, Maria Nilce Sousa& Galvão, Stanley de Sousa Lima…[et al.]. 2017. The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181598
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arruda, Mariana Oliveira…[et al.]. The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1181598
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arruda, Mariana Oliveira& Mendes, Saulo José Figueiredo& Teixeira, Simone A.& de Mesquita, Ludmilla Santos Silva& Ribeiro, Maria Nilce Sousa& Galvão, Stanley de Sousa Lima…[et al.]. The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181598
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181598
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر