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The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages
Joint Authors
Ribeiro, Maria Nilce Sousa
Fernandes, Elizabeth S.
Teixeira, Simone A.
Monteiro-Neto, Valério
Arruda, Mariana Oliveira
Mendes, Saulo José Figueiredo
de Mesquita, Ludmilla Santos Silva
Galvão, Stanley de Sousa Lima
Muscará, Marcelo Nicolás
Source
Journal of Immunology Research
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mentha piperita L.
(peppermint) possesses antimicrobial properties, but little is known of its ability to modulate macrophages.
Macrophages are essential in bacterial infection control due to their antimicrobial functions and ability to link the innate and adaptive immune responses.
We evaluated the effects of the peppermint leaf hydroalcoholic extract (LHAE) on cultured murine peritoneal macrophages stimulated or not with lipopolysaccharide (LPS) in vitro.
Vehicle-treated cells were used as controls.
The constituents of the extract were also identified.
Epicatechin was the major compound detected in the LHAE.
LPS-induced macrophage death was reversed by incubation with LHAE (1–30 μg/ml).
Higher concentrations of the extract (≥100 μg/ml) decreased macrophage viability (49–57%) in the absence of LPS.
LHAE (1–300 μg/ml) attenuated H2O2 (34.6–53.4%) but not nitric oxide production by these cells.
At similar concentrations, the extract increased the activity of superoxide dismutase (15.3–63.5-fold) and glutathione peroxidase (34.4–73.6-fold) in LPS-treated macrophages.
Only LPS-unstimulated macrophages presented enhanced phagocytosis (3.6–6.6-fold increase) when incubated with LHAE (3–30 μg/ml).
Overall, the LHAE obtained from peppermint modulates macrophage-mediated inflammatory responses, by stimulating the antioxidant pathway in these cells.
These effects may be beneficial when the excessive activation of macrophages contributes to tissue damage during infectious disease.
American Psychological Association (APA)
Arruda, Mariana Oliveira& Mendes, Saulo José Figueiredo& Teixeira, Simone A.& de Mesquita, Ludmilla Santos Silva& Ribeiro, Maria Nilce Sousa& Galvão, Stanley de Sousa Lima…[et al.]. 2017. The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181598
Modern Language Association (MLA)
Arruda, Mariana Oliveira…[et al.]. The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages. Journal of Immunology Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1181598
American Medical Association (AMA)
Arruda, Mariana Oliveira& Mendes, Saulo José Figueiredo& Teixeira, Simone A.& de Mesquita, Ludmilla Santos Silva& Ribeiro, Maria Nilce Sousa& Galvão, Stanley de Sousa Lima…[et al.]. The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1181598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1181598